American Journal of Medical Case Reports
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American Journal of Medical Case Reports. 2021, 9(9), 438-440
DOI: 10.12691/ajmcr-9-9-1
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An Unusual Case of Secondary Pulmonary Alveolar Proteinosis in Recently Diagnosed Anti-MDA5 Positive Amyopathic Dermatomyositis

Komal Ejaz1, , Mousa Thalji1, Muhammad Ali Raza2 and Hassan Awais2

1Internal Medicine, The Wright Center For Graduate Medical Education, Scranton, PA, USA

2Internal Medicine, Conemaugh Memorial Medical Center/Temple University, Johnstown, PA, USA

Pub. Date: May 17, 2021

Cite this paper:
Komal Ejaz, Mousa Thalji, Muhammad Ali Raza and Hassan Awais. An Unusual Case of Secondary Pulmonary Alveolar Proteinosis in Recently Diagnosed Anti-MDA5 Positive Amyopathic Dermatomyositis. American Journal of Medical Case Reports. 2021; 9(9):438-440. doi: 10.12691/ajmcr-9-9-1


Amyopathic dermatomyositis (AMD) is a subtype of dermatomyositis characterized by more prominent involvement of the skin rather than muscle and often positive for melanoma differentiation-associated gene 5 (MDA-5) antibodies. The most frequent pulmonary involvement in MDA-5 positive AMD is nonspecific interstitial pneumonia. However, rare cases of pulmonary alveolar proteinosis (PAP) have also been reported. Here, we present a case of a 28-year-old male who was recently diagnosed with AMD presenting with shortness of breath and dry cough was eventually diagnosed with secondary pulmonary alveolar proteinosis. This case underscores the multidisciplinary approach and diagnostic challenges associated with the diagnosis of PAP secondary to the rarity of the condition.

Amyopathic Dermatomyositis secondary pulmonary alveolar proteinosis PAP MDA-5

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