American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: Editor-in-chief: Samy, I. McFarlane
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American Journal of Medical Case Reports. 2021, 9(7), 354-357
DOI: 10.12691/ajmcr-9-7-3
Open AccessCase Report

A Rare Case of Anti-NMDA Receptor Encephalitis Associated with an Ovarian Teratoma

Eiad Habib1, , Jay Patel2, 3, Connor Kerndt2, 3, Dan Summers2, 3 and TaLawnda Bragg2, 3

1Alfaisal University College of Medicine, Riyadh, Saudi Arabia 11533

2Department of Internal Medicine, Spectrum Health Butterworth Hospital, Grand Rapids, Michigan, USA 49503

3Michigan State University College of Human Medicine, Grand Rapids, Michigan, USA

Pub. Date: April 06, 2021

Cite this paper:
Eiad Habib, Jay Patel, Connor Kerndt, Dan Summers and TaLawnda Bragg. A Rare Case of Anti-NMDA Receptor Encephalitis Associated with an Ovarian Teratoma. American Journal of Medical Case Reports. 2021; 9(7):354-357. doi: 10.12691/ajmcr-9-7-3


Anti-N-methyl-D-aspartate (NMDA)-receptor encephalitis is a syndrome of psychiatric symptoms and neurologic sequelae that is commonly associated with an ovarian teratoma. The antagonism of cerebral NMDA receptors disrupts normal brain activity causing acute onset psychological disturbances including mania, psychosis, or anxiety. Due to the rarity of the condition, diagnosis may be delayed as other common disorders such as primary psychiatric disorders or infectious encephalitis are ruled out. With rapid diagnosis and management, including resection of the tumor and immunotherapy, positive outcomes may be achieved. We present the case of a 25-year-old female with neuropsychiatric manifestations and an ovarian teratoma who was subsequently diagnosed with anti-NMDA-receptor encephalitis.

paraneoplastic anti-NMDA receptor encephalitis ovarian teratoma

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