American Journal of Medical Case Reports
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American Journal of Medical Case Reports. 2020, 8(12), 494-495
DOI: 10.12691/ajmcr-8-12-17
Open AccessCase Report

Appendicitis: In the Times of COVID-19

Asim Haider1, , Maham A. Mehmood1 and Ayesha Siddiqa1

1Department of Medicine, Bronx Care Health System, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, NY, USA

Pub. Date: September 17, 2020

Cite this paper:
Asim Haider, Maham A. Mehmood and Ayesha Siddiqa. Appendicitis: In the Times of COVID-19. American Journal of Medical Case Reports. 2020; 8(12):494-495. doi: 10.12691/ajmcr-8-12-17


Coronavirus disease -19 (COVID-19) is a novel contagious infection initially thought to be a respiratory pathogen, but there is increasing evidence of multisystem involvement. Here, we report a 43-year-old male who presented with acute abdominal pain associated with fever and chills and was diagnosed with acute appendicitis. He was tested positive for COVID-19, and because of elevated inflammatory markers, the patient was successfully managed non-operatively with remdesiver and intravenous (IV) antibiotics. Our patient had predominantly abdominal findings, and we believe that that there is a possibility that appendicitis may be associated with COVID-19.

corona virus disease 2019 acute appendicitis remdesivir

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[1]  J.F. Chan, S. Yuan, K.H: Kok, et al.A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020:514-523.
[3]  A.C. Alder, T.B. Fomby, W.A. Woodward, R.W. Haley, G: Sarosi, E.H. Livingstonassociation of viral infection and appendicitis Arch Surg. 145: 63-71.
[4]  Baird DLH, Simillis C, Kontovounisios C, Rasheed S, Tekkis PP: Acute appendicitis. BMJ. 2017; 357, 1703-2017.
[5]  Hansson J, Körner U, Khorram-Manesh A, Solberg A, Lundholm K: Randomized clinical trial of antibiotic therapy versus appendicectomy as primary treatment of acute appendicitis in unselected patients [published correction appears in. Br J Surg. 2009 Jul, 830: 473-481.
[6]  Vons C, Barry C, Maitre S, et al.: Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: an open-label, non-inferiority, randomised controlled trial. Lancet. 2011, 377: 1573-1579.
[7]  Haijanen J, Sippola S, Tuominen R, et al.: Cost analysis of antibiotic therapy versus appendectomy for treatment of uncomplicated acute appendicitis: 5-year results of the APPAC randomized clinical trial. PLoS One. 2019: 0220202-2019.
[8]  Eriksson S, Granström L: Randomized controlled trial of appendicectomy versus antibiotic therapy for acute appendicitis. Br J Surg. 1995, 82:166-169.
[9]  Arnbjörnsson E, Bengmark S: Obstruction of the appendix lumen in relation to pathogenesis of acute appendicitis. Acta Chir Scand. 1983, 149:789-791.
[10]  Stokes EK, Zambrano LD, Anderson KN, et al.: Coronavirus Disease 2019 Case Surveillance - United States, January 22-May 30. 2020. MMWR Morb Mortal Wkly Rep, 2020: 759-765.
[11]  Huang C, Wang Y, Li X, et al.: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [published correction appears in. Lancet. 2020 Jan, 30: 497-506.