American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: http://www.sciepub.com/journal/ajmcr Editor-in-chief: Samy, I. McFarlane
Open Access
Journal Browser
Go
American Journal of Medical Case Reports. 2020, 8(11), 394-396
DOI: 10.12691/ajmcr-8-11-4
Open AccessArticle

Metastatic Lung Carcinoma to Skull, an Atypical Presentation with Atypical Radiologic Features: A Case Report

Arturs Balodis1, 2, , Davis Simanis Putrins1, Julija Dolgopolova3, Inese Briede4, Renars Putnins3 and Ginta Balode5

1Institute of Diagnostic Radiology, Pauls Stradins Clinical University Hospital, Riga, Latvia

2Department of Radiology, Riga Stradins University, Riga, Latvia

3Department of Neurosurgery, Pauls Stradins Clinical University Hospital, Riga, Latvia

4Department of Pathology, Pauls Stradins Clinical University Hospital, Riga, Latvia

5Department of Infectology, Riga Stradins University, Riga, Latvia

Pub. Date: July 22, 2020

Cite this paper:
Arturs Balodis, Davis Simanis Putrins, Julija Dolgopolova, Inese Briede, Renars Putnins and Ginta Balode. Metastatic Lung Carcinoma to Skull, an Atypical Presentation with Atypical Radiologic Features: A Case Report. American Journal of Medical Case Reports. 2020; 8(11):394-396. doi: 10.12691/ajmcr-8-11-4

Abstract

A 65-year-old male patient was referred to a university hospital with a skull mass and previous history of left lung carcinoma, although a left sided pneumonectomy had been performed two years ago. The large solitary extra-axial, intra- and extra-osseous skull mass exhibited uncharacteristic radiologic features that were atypical for all of the proposed differential diagnoses, which included metastasis, atypical meningioma, and osteosarcoma. An incomplete patient history also made the radiologic diagnosis more difficult. In the end a tumour excision was performed and the tissue morphology and immunohistochemical properties examined, and the diagnosis of a metastatic lung carcinoma to the skull was confirmed.

Keywords:
skull mass metastasis lung carcinoma

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Figures

Figure of 5

References:

[1]  Osborn A.G. (2005) Extra-Axial Neoplasms, Cysts and Tumor-Like Lesions. In: Gourtsoyiannis N.C., Ros P.R. (eds) Radiologic-Pathologic Correlations from Head to Toe. Springer, Berlin, Heidelberg.
 
[2]  Ryan C. Turner, Brandon P. Lucke-Wold, Roy Hwang, Bill D. Underwood, Lung cancer metastasis presenting as a solitary skull mass, Journal of Surgical Case Reports, Volume 2016, Issue 6, June 2016, rjw116.
 
[3]  Montezuma Felizardo, Diana & Azevedo, Rosa & Lopes, Paula & Vieira, Renata & Cunha, Ana & Henrique, Rui. (2013). A panel of four immunohistochemical markers (CK7, CK20, TTF-1, and P63) allows accurate diagnosis of primary and metastatic lung carcinoma on biopsy specimens. Virchows Archiv: an international journal of pathology. 463.
 
[4]  Fernandes GL, Natal MRC, da Cruz CLP, Nascif RL, Tsuno NSG, Tsuno MY. Primary osteosarcoma of the cranial vault. Radiol Bras. 2017; 50(4): 263-265.
 
[5]  Roller LA, Chebib I, Bredella MA, Chang CY. Clinical, radiological, and pathological features of extraskeletal osteosarcoma. Skeletal Radiol. 2018; 47(9): 1213-1220.
 
[6]  Pons Escoda A, Naval Baudin P, Mora P, et al. Imaging of skull vault tumors in adults. Insights Imaging. 2020; 11(1): 23. Published 2020 Feb 13.
 
[7]  M. Pons Perell√≥, B. M. Rodr√≠guez Chikri, P. Roig Egea, R. Grau Sola, D. A. Torres Gamboa, J. Castell Aulet, C. Nieto Garcia, A. Mas Bonet, M. J. Picado. Atypical meningiomas: key radiological findings, ECR 2018.
 
[8]  Kunimatsu, A., Kunimatsu, N., Kamiya, K. et al. Variants of meningiomas: a review of imaging findings and clinical features. Jpn J Radiol 34, 459-469 (2016).
 
[9]  Tamrazi B, Shiroishi MS, Liu CS. Advanced Imaging of Intracranial Meningiomas. Neurosurg Clin N Am. 2016; 27(2): 137-143.
 
[10]  Ryu KH, Baek HJ, Cho SB, et al. Skull metastases detecting on arterial spin labeling perfusion: Three case reports and review of literature. Medicine (Baltimore). 2017; 96(44): e8432.
 
[11]  Coleman RE. Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res. 2006; 12(20 Pt 2): 6243s-6249s.
 
[12]  Gomez, C.K., Schiffman, S.R. & Bhatt, A.A. Radiological review of skull lesions. Insights Imaging 9, 857-882 (2018).
 
[13]  Schneider T, Kuhne JF, Bittrich P, et al. Edema is not a reliable diagnostic sign to exclude small brain metastases. PLoS One. 2017; 12(5): e0177217. Published 2017 May 11.
 
[14]  Mitsuya K, Nakasu Y, Horiguchi S, et al. Metastatic skull tumors: MRI features and a new conventional classification. J Neurooncol. 2011; 104(1): 239-245.