American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: Editor-in-chief: Samy, I. McFarlane
Open Access
Journal Browser
American Journal of Medical Case Reports. 2020, 8(9), 306-310
DOI: 10.12691/ajmcr-8-9-12
Open AccessCase Report

Anti-EJ Antisynthetase Syndrome Associated with Mycobacterium Tuberculosis Infection

Michael Trevisonno1, , Daniel E. Diaz2, Steven S. Chin3, FCAP Jenny Libien2 and Yamen Homsi4

1Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, USA

2Department of Pathology, State University of New York Downstate Medical Center, Brooklyn, USA

3Therapath Neuropathology, New York, USA

4Department of Rheumatology, New York University Langone Hospital, Brooklyn, USA

Pub. Date: June 08, 2020

Cite this paper:
Michael Trevisonno, Daniel E. Diaz, Steven S. Chin, FCAP Jenny Libien and Yamen Homsi. Anti-EJ Antisynthetase Syndrome Associated with Mycobacterium Tuberculosis Infection. American Journal of Medical Case Reports. 2020; 8(9):306-310. doi: 10.12691/ajmcr-8-9-12


Antisynthetase Syndrome is a rare type of idiopathic inflammatory myopathy. It is characterized by interstitial lung disease, non-erosive arthritis, Raynaud’s phenomenon, and mechanic’s hands. Diagnosis is confirmed with the detection of an antibody directed against amino-acyl transferase RNA. Opportunistic infections are common causes of mortality in patients with autoimmune diseases. Immunosuppressive treatment further contributes to the risk of infection. We report, for the first time in the literature, a 62-year-old woman diagnosed with Anti-EJ antisynthestase syndrome who died from disseminated mycobacterial tuberculosis infection. This case emphasizes the importance of early recognition and prompt treatment of opportunistic infections in order to decrease mortality.

antisynthetase syndrome Anti-EJ antibody idiopathic inflammatory myopathy mycobacterium tuberculosis

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit


[1]  Lundberg IE, de Visser M, Werth VP, “Classification of myositis”, Nat Rev Rheumatol, 14. 269-78. April 2018.
[2]  Witt LJ, Curran JJ, Strek ME, “The Diagnosis and Treatment of Antisynthetase Syndrome”, Clin Pulm Med, 23. 218-26. September 2016.
[3]  Hamaguchi Y, Fujimoto M, Matsushita T, Kaji K, Komura K, Hasegawa M Kodera M, Muroi E, Fujikawa K, Seishima M, Yamada H, Yamada R, Sato S, Takehara K, Kuwana M, “Common and distinct clinical features in adult patients with anti-aminoacyl-tRNA synthetase antibodies: heterogeneity within the syndrome”, PLos One, 8 (4). e60442. April 2013.
[4]  Aggarwal R, Cassidy E, Fertig N, Koontz DC, Lucas M, Ascherman DP, Oddis CV, “Patients with non-Jo-1 anti-tRNA-synthetase autoantibodies have worse survival than Jo-1 positive patients”, Ann Rheum Dis, 73(1). 227-32. February 2013.
[5]  Sasano H, Hagiwara E, Kitamura H, Enomoto Y, Matsuo N, Baba T, Iso S, Okudela K, Iwasawa T, Sato S, Suzuki Y, Takemura T, Ogura T, “Long-term clinical course of anti-glycyl tRNA synthetase (anti-EJ) antibody-related interstitial lung disease pathologically proven by surgical lung biopsy”, BMC Pulm Med, 16(1). 168. December 2016.
[6]  Noguchi E, Uruha A, Suzuki S, Hamanaka K, Ohnuki Y, Tsugawa J, Watanabe Y, Nakahara J, Shiina T, Suzuki N, Nishino I, “Skeletal Muscle Involvement in Antisynthetase Syndrome”, JAMA Neurol, 74(8). 992-9. August 2017.
[7]  Alarcón GS, “Infections in systemic connective tissue diseases: systemic lupus erythematosus, scleroderma, and polymyositis/dermatomyositis”, Infect Dis Clin North Am, 20(4). 849-75. November 2006.
[8]  Marie I, Hachulla E, Chérin P, Hellot MF, Herson S, Levesque H, Haltron PY, “Opportunistic infections in polymyositis and dermatomyositis”, Arthritis Rheum, 53(2). 155-65. April 2005.
[9]  Kim HA, Yoo CD, Baek HJ, Lee EB, Ahn C, Han JS, Kim S, Lee JS, Choe KW, Song YW, “Mycobacterium tuberculosis infection in a corticosteroid-treated rheumatic disease patient population”, Clin Exp Rheumatol, 16(1). 9-13. January 1998.
[10]  Hernández-Cruz B, Sifuentes-Osornio J, Ponce-de-León Rosales S, Ponce-de-León Garduno A, Diaz-Jouanen E, “Mycobacterium tuberculosis infection in patients with systemic rheumatic diseases. A case-series”, Clin Exp Rheumato, 17(3). 289-96. May 1999.