American Journal of Medical Case Reports
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American Journal of Medical Case Reports. 2020, 8(7), 162-165
DOI: 10.12691/ajmcr-8-7-1
Open AccessCase Report

Pulmonary Sarcomatoid Giant Cell Carcinoma with Paraneoplastic Hypertrophic Osteoarthropathy: A Case Report

Osagie Igiebor1, Rishard Abdul1, Natalie Sun1, Leen Khoury1, Gil Hevroni1 and Samy I. McFarlane1,

1Department of Internal Medicine, SUNY- Downstate Health Science University, 450 Clarkson Avenue, Box 50, Brooklyn, NY 11203

Pub. Date: April 12, 2020

Cite this paper:
Osagie Igiebor, Rishard Abdul, Natalie Sun, Leen Khoury, Gil Hevroni and Samy I. McFarlane. Pulmonary Sarcomatoid Giant Cell Carcinoma with Paraneoplastic Hypertrophic Osteoarthropathy: A Case Report. American Journal of Medical Case Reports. 2020; 8(7):162-165. doi: 10.12691/ajmcr-8-7-1


Giant-cell carcinoma of the lung (GCCL) is a rare histological form of poorly differentiated non-small-cell lung cancer, which is classified as a subtype of pulmonary sarcomatoid carcinomas. In this case report, we describe the case of a 57 year old female with a past medical history of HIV on HAART (CD4 count at the time was 621 cell/┬Ál) .She presented to the hospital with a two months history of productive cough with yellowish sputum containing streaks of blood, twelve pound weight loss, bilateral hand swelling, and knee pain with noticeable finger clubbing on physical examination. Chest computed tomography scan and subsequent bronchoscopy was performed and revealed a protruding endobronchial lesion in the right upper lobe (RUL) bronchus. Definitive diagnosis established by way of pathologic analysis of the resected specimen obtained from RUL lobectomy revealed sarcomatoid giant cell carcinoma, with tumor size 9.5 cm and invasion of the visceral pleura and 1/13 hilar lymph node involvement. The pathological stage was determined as pT3N1Mx based on the tumor node metastasis (TNM) staging system. The patient was started on adjuvant combination cisplatin and docetaxel therapy with supplemental G-CSF four months after surgery and followed as an outpatient. The significance of this case is that it highlights a very rare lung cancer, unveiling a possible paraneoplastic syndrome associated with this malignancy and the impact of HIV HAART therapy in carcinogenesis.

giant cell carcinoma paraneoplastic hypertrophic osteoarthropathy

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[1]  N.F. Fishback, W.D. Travis, C.A. Moran, D.G. Guinee Jr., W.F. McCarthy, C.A. Koss Pleomorphic (spindle/giant cell) carcinoma of the lung: a clinicopathologic correlation of 78 cases Cancer, 73 (1994), pp. 2936-2945.
[2]  M. Nakajima, T. Kasai, H. Hashimoto, Y. Iwata, H. Manabe. Sarcomatoid carcinoma of the lung: a clinicopathologic study of 37 cases Cancer, 86 (1999), pp. 608-616.
[3]  G. Rossi, A. Cavazza, N. Sturm, M. Migaldi, N. Facciolongo, L. Longo, et al. Pulmonary carcinomas with pleomorphic, sarcomatoid or sarcomatous elements: a clinicopathologic and immunohistochemical study of 75 cases. Am J Surg Pathol, 27 (2003), pp. 311-324.
[4]  W.D. Travis, L.B. Travis, S.S. Devesa; Lung cancer. Cancer, 75 (1995), pp. 191-202.
[5]  D. Travis, E. Brambillia, K. Muller-Hermelink, C.C. Harris (Eds.), WHO classification of tumours. Pathology and genetics. Tumor of the lung, pleura, thymus and heart, IARC Press, Ryon (2004), pp. 53-58.
[6]  Spiro SG, Gould MK, Colice GL. Initial evaluation of the patient with lung cancer: symptoms, signs, laboratory tests, and paraneoplastic syndromes: ACCP evidenced-based clinical practice guidelines (2nd edition) Chest. 2007; 132: 149S-160S.
[7]  Nobuhiro Kanaji, Naoki Watanabe, Nobuyuki Kita, Shuji Bandoh, Akira Tadokoro, Tomoya Ishii, Hiroaki Dobashi, and Takuya Matsunaga; Paraneoplastic syndromes associated with lung cancer. World J Clin Oncol. 2014 Aug 10; 5(3): 197-223.
[8]  Martin, Linda W. et al. Sarcomatoid Carcinoma of the Lung: A Predictor of Poor Prognosis. The Annals of Thoracic Surgery, Volume 84, Issue 3, 973-980.
[9]  Beasley, Mary Beth et al. The 2004 World Health Organization classification of lung tumors, Seminars in Roentgenology, Volume 40, Issue 2, 90-97.
[10]  Travis, William D. et al, The 2015 World Health Organization Classification of Lung Tumors,Journal of Thoracic Oncology, Volume 10, Issue 9, 1243-1260.
[11]  Yendamuri S, Caty L, Pine M, et al. Outcomes of sarcomatoid carcinoma of the lung: a Surveillance, Epidemiology, and End Results Database analysis. Surgery 2012; 152 (3): 397-402.
[12]  Vieira, Thibault et al,Efficacy of First-Line Chemotherapy in Patients with Advanced Lung Sarcomatoid Carcinoma Journal of Thoracic Oncology , Volume 8 , Issue 12 , 1574-1577.
[13]  Huang S-Y, Shen S-J, Li X-Y. Pulmonary sarcomatoid carcinoma: a clinicopathologic study and prognostic analysis of 51 cases. World Journal of Surgical Oncology. 2013; 11: 252.
[14]  Raveglia, Federico et al ,Personal Experience in Surgical Management of Pulmonary Pleomorphic Carcinoma,The Annals of Thoracic Surgery, Volume 78, Issue 5, 1742-1747.
[15]  Panagiotis Hountis, Sotirios Moraitis, Panagiotis Dedeilias, Polychronis Ikonomidis and Mattheos Douzinas, Sarcomatoid lung carcinomas: a case series. Cases Journal 2009, 2: 7900.