American Journal of Medical Case Reports
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American Journal of Medical Case Reports. 2019, 7(9), 184-190
DOI: 10.12691/ajmcr-7-9-1
Open AccessCase Report

Argatroban-refractory, Heparin-induced Thrombocytopenia after Coronary Intervention with Radial Artery Occlusion

Mohammed Al-Sadawi1, Michael Haddadin1, Violeta Capric1 and Samy I. McFarlane1,

1Department of Internal Medicine, State University of New York: Downstate Medical Center, Brooklyn, New York, United States-11203

Pub. Date: July 14, 2019

Cite this paper:
Mohammed Al-Sadawi, Michael Haddadin, Violeta Capric and Samy I. McFarlane. Argatroban-refractory, Heparin-induced Thrombocytopenia after Coronary Intervention with Radial Artery Occlusion. American Journal of Medical Case Reports. 2019; 7(9):184-190. doi: 10.12691/ajmcr-7-9-1


Heparin induced thrombocytopenia (HIT) is serious disorder that occurs in a small percentage of patients following exposure to heparin. HIT can further be classified into two types: HIT type 1 and type 2. Type 2 HIT is a potentially life threatening with clinically significant outcomes. It presents with thrombocytopenia and evidence of thrombus formation in the presence of antibody formation. Additionally, several variations of HIT exist, including delayed onset HIT and refractory HIT, known collectively as autoimmune HIT (aHIT). Here we present a case of delayed onset and refractory HIT in a patient with little heparin exposure, discovered only after cardiac intervention for suspected STEMI. Significant thrombotic events occurred thereafter, including radial artery stenosis and intracardiac thrombus. Treatment with argatroban was ineffective. Significant resolution of thrombocytopenia was seen several weeks after infusion with IVIG, thus depicting further suspicion for refractory HIT. IVIG for aHIT treatment is traditionally chosen only if the disease process is refractory to other anticoagulation efforts due to the potential risk for increasing thrombotic risk with IVIG infusion. Our case illistrate the rare presentation of aHIT and the use if IVIG to successfully treat thrombocytopenia in refractory HIT.

heparin-induced thrombocytopenia radial artery occlusion coronary intervention complications

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