Leukocytosis Associated with Esophageal Squamous Cell Carcinoma as a Predictor of Poor Prognosis - A Case Report and Review of Literature

Apoorva Jayarangaiah¹, Pramod Theetha Kariyanna², Tanuj Chokshi², Maya Srinivasan², Seline Asun², Michael Ashamalla², Irini Youssef² and Samy I McFarlane^2,

¹Department of Internal Medicine, NYC Health and Hospitals/Jacobi Medical Center, Bronx, N.Y., U.S.A- 10461

²Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, N.Y, U.S.A- 11203

Cite this paper:
Apoorva Jayarangaiah, Pramod Theetha Kariyanna, Tanuj Chokshi, Maya Srinivasan, Seline Asun, Michael Ashamalla, Irini Youssef and Samy I McFarlane. Leukocytosis Associated with Esophageal Squamous Cell Carcinoma as a Predictor of Poor Prognosis - A Case Report and Review of Literature. American Journal of Medical Case Reports. 2019; 7(1):9-12. doi: 10.12691/ajmcr-7-1-3

Abstract

Leukocytosis, specifically granulocytosis in malignancy is a common finding with various etiologies. Graulocytosis associated with esophageal cancer has not commonly been reported in case reports in the United States. Furthermore, granulocyte colony stimulating factor (G-CSF) producing tumors have been associated with a variety of cancers. However, G-CSF producing esophageal tumors are rare. The diagnosis is established through serum G-CSF levels and immunohistochemistry staining of tumor cells. Here, we report a case of a 72-year-old woman with persistent granulocytosis leading to the diagnosis of esophageal squamous cell carcinoma (ESCC). Although, our case did not report serum G-CSF levels, we strongly suspect it to be the underlying etiology in our case. Additionally, through our missed opportunity, we hope to emphasize and increase awareness of G-CSF producing ESCC.

Keywords:
esophageal squamous cell carcinoma leukocytosis granulocyte colony stimulating factor (G-CSF)

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References:

[1]	Hocking, W., Goodman, J., Goode, D. (1983) Granulocytosis associated with tumor cell production of colony-stimulating activity. Blood. 61 (3), 600-603.
[2]	Robinson WA. Granulocytosis in neoplasia. Ann N Y Acad Sci. 1974; 230: 212-218.
[3]	Fukuda, S., Fujiwara, Y., Mishima, H. et al. (2017). Choroidal metastasis from granulocyte colony-stimulating factor-producing esophageal squamous cell carcinoma: a case report. Clinical Case Reports, 5(4), 419-424.
[4]	Kitani, M., Yamagata, Y., Tanabe, A. et al. (2016). Radical esophagectomy for a 92-year-old woman with granulocyte colony-stimulating factor-producing esophageal squamous cell carcinoma: a case report. World Journal of Surgical Oncology, 14(1).
[5]	Mayanagi, S., Niihara, M., Goto, H., Yokota, T., Tabuse, H., Yasui, H., … Tsubosa, Y. (2013). Granulocyte colony-stimulating factor-producing esophageal squamous cell carcinoma following chemoradiotherapy and bone marrow transplantation for acute lymphoblastic leukemia. Esophagus, 10(4), 258-263.
[6]	Watanabe, H. A., Matsushita, H., Matsui, H. et al. (1999). Esophageal carcinoma with high serum parathyroid hormone-related protein (PTHrP) level. Journal of Gastroenterology, 34(4), 510-515.
[7]	Ota, S., Kato, A., Kobayashi, H. (1998). Monoclonal origin of an esophageal carcinosarcoma producing granulocyte-colony stimulating factor. Cancer, 82: 2102-2111.
[8]	Yamaguchi, S., Kanetaka, K., Kobayashi, S. et al. (2017). Severe neutrophilic leukocytosis as a progression marker in granulocyte colony-stimulating factor-producing squamous cell carcinoma of the esophagus. Clinical Case Reports, 5(5), 688-693.
[9]	Ichiishi, E. (2000). Possible paracrine growth of adenocarcinoma of the stomach induced by granulocyte colony stimulating factor produced by squamous cell carcinoma of the oesophagus. Gut, 46(3), 432-434.
[10]	Matsumoto, G., Ise, H., Kimura, Y. et al. (2000). Granulocyte-colony stimulating factor-producing esophageal carcinoma: serum level as a marker for monitoring the effects of treatment. International Journal of Clinical Oncology, 5(5), 328-333.
[11]	Nakata, K., Ohtsuka, T., Sato, S. et al. (2006). Esophageal carcinoma with humoral hypercalcemia and leukocytosis successfully treated by a two-stage operation: report of a case. Esophagus, 3(1), 13-17.
[12]	Kato, M., H. Osawa, N. Usui, and H. Hano. 2002. Anautopsy case of esophageal squamous cell carcinoma associated with granulocyte colony-stimulating factor production. Jikeikai Med. J. 49: 191-95.
[13]	Eto, K., Watanabe, M., Iwatsuki, M. et al (2013). Granulocyte-colony-stimulating factor producing esophageal squamous cell carcinoma: a report of 3 cases. International Cancer Conference Journal, 2(3), 149-153.
[14]	Komatsu, D., Sakurai, M., Nakafuji, H. et al. (2003). Granulocyte colony stimulating factor-producing collision tumor of the gastric cardia. Journal of Gastroenterology, 38(10), 1013-1015.
[15]	Mimatsu, K., Oida, T., Kano, H., Kawasaki, A., & Amano, S. (2008). Aggressive progression of granulocyte colony-stimulating factor producing squamous cell carcinoma of the esophagus: case report and literature review. Esophagus, 5(4), 205-209.
[16]	Oshikiri, T., Yasuda, T., Harada, H. et al. (2014). G-CSF-producing esophageal cancer with induction of intense bone marrow FDG uptake. Esophagus, 12(3), 258-262.
[17]	Shimakawa, T., Asaka, S., Usuda, A. et al. (2014). Granulocyte-Colony Stimulating Factor (G-CSF)-Producing Esophageal Squamous Cell Carcinoma: A Case Report. International Surgery, 99(3), 280-285.
[18]	Tanabe, T., Kanda, T., Ishihara, N. et al. (2009). An esophageal squamous cell carcinoma patient with high serum granulocyte-colony stimulating factor level: report of a case. Esophagus, 6(4), 253-258.
[19]	Kashiwamura, S. Yoshikawa, M., Murai, H. (1994) Case of esophageal cancer with hypercalcemia and leukocytosis. Nihon Naika Gakkai Zasshi. 1994 Feb 10; 83(2): 299-300.
[20]	Schernberg, A., Moureau-Zabotto, L., Del Campo, E. et al (2017). Leukocytosis and neutrophilia predict outcome in locally advanced esophageal cancer treated with definitive chemoradiation. Oncotarget, 8(7).
[21]	Zhou, X., Li, Y., Zhu, W., et al (2017). Neutrophil-to-lymphocyte ratio as a prognostic biomarker for patients with locally advanced esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. Scientific Reports, 7, 42581.
[22]	Groblewska, M., Mroczko, B., Sosnowska, D., & Szmitkowski, M. (2012). Interleukin 6 and C-reactive protein in esophageal cancer. Clinica Chimica Acta, 413(19-20), 1583-1590.
[23]	Hoshimoto, S., Hoshi, N., Ozawa, I. et al. (2018). Rapid progression of a granulocyte colony-stimulating factor-producing liver tumor metastasized from esophagogastric junction cancer: A case report and literature review. Oncology Letters.
[24]	Erpenbeck, L., & Schön, M. P. (2016). Neutrophil extracellular traps: protagonists of cancer progression? Oncogene, 36(18), 2483-2490.