American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: http://www.sciepub.com/journal/ajmcr Editor-in-chief: Samy, I. McFarlane
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American Journal of Medical Case Reports. 2019, 7(1), 9-12
DOI: 10.12691/ajmcr-7-1-3
Open AccessArticle

Leukocytosis Associated with Esophageal Squamous Cell Carcinoma as a Predictor of Poor Prognosis - A Case Report and Review of Literature

Apoorva Jayarangaiah1, Pramod Theetha Kariyanna2, Tanuj Chokshi2, Maya Srinivasan2, Seline Asun2, Michael Ashamalla2, Irini Youssef2 and Samy I McFarlane2,

1Department of Internal Medicine, NYC Health and Hospitals/Jacobi Medical Center, Bronx, N.Y., U.S.A- 10461

2Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, N.Y, U.S.A- 11203

Pub. Date: January 22, 2019

Cite this paper:
Apoorva Jayarangaiah, Pramod Theetha Kariyanna, Tanuj Chokshi, Maya Srinivasan, Seline Asun, Michael Ashamalla, Irini Youssef and Samy I McFarlane. Leukocytosis Associated with Esophageal Squamous Cell Carcinoma as a Predictor of Poor Prognosis - A Case Report and Review of Literature. American Journal of Medical Case Reports. 2019; 7(1):9-12. doi: 10.12691/ajmcr-7-1-3

Abstract

Leukocytosis, specifically granulocytosis in malignancy is a common finding with various etiologies. Graulocytosis associated with esophageal cancer has not commonly been reported in case reports in the United States. Furthermore, granulocyte colony stimulating factor (G-CSF) producing tumors have been associated with a variety of cancers. However, G-CSF producing esophageal tumors are rare. The diagnosis is established through serum G-CSF levels and immunohistochemistry staining of tumor cells. Here, we report a case of a 72-year-old woman with persistent granulocytosis leading to the diagnosis of esophageal squamous cell carcinoma (ESCC). Although, our case did not report serum G-CSF levels, we strongly suspect it to be the underlying etiology in our case. Additionally, through our missed opportunity, we hope to emphasize and increase awareness of G-CSF producing ESCC.

Keywords:
esophageal squamous cell carcinoma leukocytosis granulocyte colony stimulating factor (G-CSF)

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