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American Journal of Medical and Biological Research. 2013, 1(4), 138-144
DOI: 10.12691/ajmbr-1-4-6
Open AccessArticle

Growth Dynamics of CD4 cells in HIV-1 Patients on Antiretroviral Therapy (ART) at the Builsa District Hospital in Ghana

Albert Luguterah1 and Mustapha Adams1,

1Department of Statistics, University for Development Studies, Ghana

Pub. Date: December 01, 2013

Cite this paper:
Albert Luguterah and Mustapha Adams. Growth Dynamics of CD4 cells in HIV-1 Patients on Antiretroviral Therapy (ART) at the Builsa District Hospital in Ghana. American Journal of Medical and Biological Research. 2013; 1(4):138-144. doi: 10.12691/ajmbr-1-4-6


The monitoring of CD4 counts are a basis for assessing the effectiveness of most HIV treatments. Understanding the way CD4 cells change over time among patients on ART could provide insight into the way Patients respond to treatment and how effective treatment is with time. This study examine the changes in CD4 countover time and the effect of some plausible factors on this change for Patients who were on Antiretroviral Therapy(ART) in The Builsa District Hospital in Ghana. Retrospective data from the HIV/AIDS Monitoring Program at the Builsa District hospital, in which patients had enrolled and their CD4 cell count were regularly being monitored every six months, forming repeated measures of CD4 counts, was used for our study: Profile analysis was used to study the pattern of change in the CD4 count. While treatment remained effective, the results showed that the trend of CD4 count over time was logarithmic indicating that the effectiveness of treatment, decreased with time. While the gender and marital status of the patientsdo not show any statistically significant differentials to this, the educational and religious status of the patients, as well as the drug used in the treatment do.

HIV CD4 cells antiretroviral therapy profile analysis

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[1]  Louise C (2011), History of HIV/AIDS, WebMD, LLC. Available at aids-retrospective. (Accessed on 12-04-2013).
[2]  UNAIDS (2012), Report on the global AIDS epidemic, UNAIDS / JC2417E. Available at:,76121,en.asp (Accessed on June 14, 2013).
[3]  Maria, P. M., Robertsonb, J. R., Brettlec, R. P., Aguadod, I. H., Barbara, B., Boufassaf, F., Van den Hoeka, A. (1999). Do Gender differences in CD4 cell counts matter. AIDS, 13(17): 2361-4.
[4]  Ssewanyana, I., Elrefaei, M., Dorsey, G., Ruel, T., Jones, N. G., Gasasira, A., Cao, H. (2007). Profile of T cell Immune Responses in Hiv-Infected Children from Uganda. The Journal of Infectious Diseases, 196: 1667-70.
[5]  Kumarasamy, N., Venkatesh, K. K., Cecelia, A. J., Devaleenol, B., Saghayam, S., Yepthomi, T., Mayer, K. H. (2008). Gender-Based Differences in Treatment and Outcome among HIV Patients in South India. Journal of Women's Health, 17(9): 1471-1475.
[6]  Zhou, J., Sirisanthana, T., Kiertiburanakul, S., Chen, Y. M., Han, N., Lim, P. L., Law, M. G. (2010). Trends in CD4 counts in HIV-Infected patients with HIV viral load monitoring while on combination antiretroviral treatment: results from the TREAT Asia HIV Observational Database. BMC Infectious Diseases, 10:361.
[7]  Williams, B. G., Korenromp, E. L., Gouws, E., Schmid, G. P., Auvert, B., & Dye, C. (2006). HIV Infection, Antiretroviral Therapy, and CD4+ Cell Count Distributions in African Populations. The Journal of Infectious Diseases, 194 (10): 1450-1458.
[8]  Paul, E. Sax, Stephen L. Boswell, Margaret, W.G and Martin S. H(1995), Potential Clinical Implications of Inter laboratory Variability in CD4+ T-Lymphocyte Counts of Patients Infected with Human Immunodeficiency Virus. Clinical Infectious Diseases Vol. 21, No., pp. 1121-1125. Published by: Oxford University Press.
[9]  Mark C (2007), Living with HIV, A patient’s Guide, (Accessed 0n 06-06-2013)
[10]  Rodriguez, W. R., Christodoulides N, Floriano, P. N, Graham S, Mohanty S, , Meredith D, Trevor P, Shabnam Z, Ibou T, Dwight R, Bruce B, Adrian P G, Bruce D, John T M (2005) A Microchip CD4 Counting Method for HIV Monitoring in Resource-Poor Settings. PLoS Med 2(7): e182.
[11]  WHO, UNAIDS, UNICEF (2004),Towards Universal Access. Scaling up priority HIV/AIDS interventions in the health sector. Progress report 2004. World Health Organization, Geneva 2004. Available at: [Accessed March 28, 2013].
[12]  Ajayi, A. O., Ajayi, E. A., & Fasakin, K. A. (2009). CD4+ T-lymphocytes cell counts in adults with human immunodeficiency virus infection at the medical department of a tertiary health institution in Nigeria. Annals of African Medicine, 8(4):257-60.
[13]  McMahon, J., Wanke, C., Terrin, N., Skinner, S., & Knox, T. (2011). Poverty, Hunger, Education, and Residential Status Impact Survival in HIV. AIDS and Behaviour, 15(7): 1503-1511.
[14]  Chaisson, R. E., Keruly, J. C., & Moore, R. D. (1995). Race, sex, drug use, and progression of human immunodeficiency virus disease. The New England Journal of Medicine, 333(12):751-6.
[15]  Mair, C., Hawes, S. E., Agne, H. D., Sow, P. S., N'doye, I., Manhart, L. E., Kiviat, N. B. (2008). Factors associated with CD4 lymphocyte counts in HIV-negative Senegalese individuals. Clinical & Experimental Immunology, 151(3): 432-440.
[16]  Akinbami, A., Dosunmu, A., Adediran, A., Ajibola, S., Oshinaike, O., Wright, K., & Arogundade, O. (2012). CD4 Count Pattern and Demographic Distribution of Treatment-Naïve HIV Patients in Lagos, Nigeria. AIDS Research and Treatment, 2012: Article ID 352753, 6 pages.
[17]  Rajeev, K. H., Yuvaraj, B. Y., Nagendra Gowda, M. R., & Ravikumar, S. M. (2012). Impact of HIV/AIDS on quality of life of people living with HIV/AIDS in Chitradurga district, Karnataka. Indian Journal of Public Health, 56(2): 116-121.
[18]  Catz, S. L., Kelly, J. A., Bogart, L. M., Benotsch, E. G., & McAuliffe, T. L. (2000). Patterns, Correlates and Barriers to Medication adherence among Persons Prescribed new Treatments for HIV disease. Health Psychology, 19(2); 124-133.
[19]  Bangsberg, D. R., Hecht, F. M., Charlebois, E. D., Zolopa, A. R., Holodniy, M., Sheiner, L., Moss, A. (2000). Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population. Journal of Acquired Immune Deficiency Syndromes, 14 (4): 357-366.
[20]  Haubrich, R. H., Little, S. J., Currier, J. S., Forthal, D. N., Kemper, C. A., Beall, G. N., Group, t. C. (1999). The value of patient-reported adherence to antiretroviral therapy in predicting virologic and immunologic response. Journal of Acquired Immune Deficiency Syndromes, 13(9):1099-1107.
[21]  Nkatazo, L. (2009), AMERICAN researchers say they have found a novel technique that can destroy the HIV virus, and prevent infection.