American Journal of Medical and Biological Research
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American Journal of Medical and Biological Research. 2017, 5(2), 13-17
DOI: 10.12691/ajmbr-5-2-1
Open AccessArticle

The Analysis of Prostaglandin E2 (PGE2), Pain Pressure Threshold (PPT), and Critical-Care Pain Observation Tools (CPOT) of Systemic Inflammatory Responses Syndrome (SIRS) Patients in Intensive Care Unit

Dwi Pantja Wibowo1, , Suryani As’ad2, Fransiscus Suhadi1, I Wayan Suranadi3, Ilhamjaya Patellongi4, Irawan Yusuf4, Mohammad Ramli Ahmad5, Syafrie Kamsul Arif5 and Andi Husni Tanra5

1Anesthesiology and Intensive Care Department, Bintaro Premier Hospital, Banten, Indonesia

2Clinical Nutrition Department, Hasanuddin University, Makassar, Indonesia

3Anesthesiology and Intensive Care Department, Udayana University, Denpasar, Indonesia

4Physiology Department, Hasanuddin University, Makassar, Indonesia

5Anesthesiology and Intensive Care Management Department, Hasanuddin University, Makassar, Indonesia

Pub. Date: July 20, 2017

Cite this paper:
Dwi Pantja Wibowo, Suryani As’ad, Fransiscus Suhadi, I Wayan Suranadi, Ilhamjaya Patellongi, Irawan Yusuf, Mohammad Ramli Ahmad, Syafrie Kamsul Arif and Andi Husni Tanra. The Analysis of Prostaglandin E2 (PGE2), Pain Pressure Threshold (PPT), and Critical-Care Pain Observation Tools (CPOT) of Systemic Inflammatory Responses Syndrome (SIRS) Patients in Intensive Care Unit. American Journal of Medical and Biological Research. 2017; 5(2):13-17. doi: 10.12691/ajmbr-5-2-1

Abstract

Sepsis is one of the major health problems with very high costs, a number of patients who survived sepsis developed long-term complications such as persistent pain. Studies found correlation of persistent pain and PGE2 level. Aims of this study were to investigate the changes in the prostaglandin E2 levels from patients with systemic inflammatory responses syndrome (SIRS) that affect pain intensity changes with the marked increase of critical-care pain observation tools (CPOT) and decreased of the pain pressure threshold (PPT). A cross-sectional analysis to compare the values of PGE2, CPOT, and PGE2 of SIRS patients and patients without SIRS. Of the 46 patients who were the subjects of the study, there were 21 SIRS patients and 25 patients, not SIRS. Patients with SIRS had higher CPOT values and PGE2 levels than patients without SIRS; CPOT values (3.3 vs. 1.2)) and PGE2 levels (6195.81 vs. 2728.67). The PPT scores of patients with SIRS were lower than those without SIRS (4.24 vs. 7.37). The CPOT was significantly correlated (p <0.05) with PGE2 (r = -0.624). We conclude that in SIRS patients there is an increase PGE2, which in turn leads to decreased pain threshold (PPT) and increased pain score (CPOT).

Keywords:
SIRS CPOT PGE2

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