American Journal of Medical and Biological Research
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American Journal of Medical and Biological Research. 2013, 1(4), 99-102
DOI: 10.12691/ajmbr-1-4-3
Open AccessArticle

Effect of Alcohol Consumption on Oxidative Stress Markers and its Role in the Pathogenesis and Progression of Liver Cirrhosis

Neelesh Deshpande1, Sabitha Kandi2, P Venkata Bharath Kumar3, K V Ramana4, and Manohar Muddeshwar1

1Department of Biochemistry, Government Medical college, Nagpur

2Department of Biochemistry, Chalmeda Anandarao Inastitute of Medical Sciences, Karimnagar

3Department of Biochemistry, Vaydehi Institute of Medical Sciences and research center, Bengaluru

4Department of Microbiology, Prathima Institute of Medical Sciences, Karimnagar

Pub. Date: October 11, 2013

Cite this paper:
Neelesh Deshpande, Sabitha Kandi, P Venkata Bharath Kumar, K V Ramana and Manohar Muddeshwar. Effect of Alcohol Consumption on Oxidative Stress Markers and its Role in the Pathogenesis and Progression of Liver Cirrhosis. American Journal of Medical and Biological Research. 2013; 1(4):99-102. doi: 10.12691/ajmbr-1-4-3

Abstract

Oxidative stress has been increasingly implicated in the pathogenesis and progression of liver cirrhosis. Chronic ethanol consumption induces an oxidative stress resulting in increased ferritin levels and thereby iron over load. The study was aimed at evaluating the relation between alcohol consumption and erythrocyte superoxide dismutase (SOD), Glutathione peroxidase (GPx), Malondialdehyde (MDA) activities in liver cirrhosis patients. The study included two groups based on alcohol consumption; subjects taking low alcohol content (Less than 150 g/day.), those consuming high alcohol content (More than 150 g/day), diagnosed as suffering from liver cirrhosis and control group who do not take alcohol and are not suffering from liver cirrhosis. All cirrhotic patients on high alcohol intake in the study group had lower serum SOD (P < 0.0001), GPx (0.0001) and significantly higher MDA levels (P<0.001) than those with subjects taking low alcohol and control group. These results suggest that the decrease in erythrocyte SOD, GPx and increase in MDA levels are related to the alcohol consumption and that may be associated with pathogenesis and progression of liver disease.

Keywords:
liver cirrhosis alcohol consumption malondialdehyde superoxide dismutase Glutathione peroxidase

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