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American Journal of Medical and Biological Research. 2016, 4(2), 26-32
DOI: 10.12691/ajmbr-4-2-3
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HIV/AIDS and Coronary Heart Disease on a Collision Course? Review of Zimbabwe

Danai Tavonga Zhou1, 2, , Olav Oktedalen3, Tawanda Chisango4 and Babill Stray-Pedersen1

1Institute of Clinical Medicine, University in Oslo, Oslo University Hospital, P.O. Box 1171, Blindern, 0318 Oslo, Norway

2University of Zimbabwe, College of Health Sciences, Department of Medical Laboratory Sciences, P. O. Box AV 178, Avondale, Harare, Zimbabwe

3Department of Infectious Diseases, Oslo University Hospital, P.O. Box 4950, Nydalen, 0424, Oslo, Norway

4Chinhoyi University of Technology, PO Box 7724, Chinhoyi, Zimbabwe

Pub. Date: July 12, 2016

Cite this paper:
Danai Tavonga Zhou, Olav Oktedalen, Tawanda Chisango and Babill Stray-Pedersen. HIV/AIDS and Coronary Heart Disease on a Collision Course? Review of Zimbabwe. American Journal of Medical and Biological Research. 2016; 4(2):26-32. doi: 10.12691/ajmbr-4-2-3

Abstract

There are very few published manuscripts on coronary heart disease (CHD) from Sub-Saharan Africa (SSA) and Zimbabwe. In fact the few published papers on the subject suggest that CHD is rare in SSA and in Zimbabwean individuals both before HIV and in the era of HIV/AIDS and antiretroviral therapy (ART). However a look at recent literature and data from publications by both the World Health Organization (WHO) and Zimbabwe Ministry of Health and Child Care point towards an epidemiological transition, as CHD is now one of the top causes of death in Zimbabwe. This may be due to the fact that CHD is a complex inflammatory disease involving smoking, obesity, diabetes, atherogenic lipid levels, cytokines and other inflammatory markers such as C reactive protein (CRP) and myeloperoxidase (MPO) and many of these factors have consistently been linked to changing lifestyle as populations move into urban settings. On the other hand, atherogenic lipids and elevated inflammatory markers are more common in HIV infected individuals due to the virus and ART. Hence it is likely that the burden of non-communicable diseases (NCDs) and CHD will increase over time as a result of both urbanization in the general population and a high HIV disease burden in Zimbabwe, pointing towards a collision of HIV and CHD in future.

Keywords:
CHD epidemiological transition HIV NCDs Zimbabwe

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References:

[1]  World Health Organization (2015) Deaths from coronary heart disease, Available @ http://www.who.int/cardiovascular_diseases/en/cvd_atlas_14_deathHD.pdf.
 
[2]  Beaglehole R, Bonita R (2008) Global public health: A scorecard. Lancet; 372(9654):1988-1996.
 
[3]  McKeown RE (2009) The Epidemiologic Transition: Changing Patterns of Mortality and Population Dynamics. American Journal of Lifestyle Medicine;3(1 Suppl):19S-26S.
 
[4]  World Health Organisation (2010) Global status report on non-communicable diseases 2010, Available @ http://www.who.int/nmh/publications/ncd_report_full_en.pdf.
 
[5]  Zimbabwe Ministry of Health and Child Care (2015) Top 50 causes of death, Available @ http://www.mohcc.gov.zw/country-health-profile/14-sample-data-articles/105-coming-soon-3.
 
[6]  World Health Organization (2015) Non communicable Diseases (NCD) Country Profiles 2014, Available @ http://www.who.int/nmh/countries/zwe_en.pdf.
 
[7]  Mbewu A, Mbanya J-C (2006) Cardiovascular Disease in Disease and Mortality in Sub-Saharan Africa. In CVD in Africa, Jamison DT, Feachem RG, Makgoba MW, et al., editors, 2nd edition. Washington (DC): World Bank.
 
[8]  BeLue R, Okoror TA, Iwelunmor J, Taylor KD, Degboe AN, Agyemang C, Ogedegbe G (2009) An overview of cardiovascular risk factor burden in sub-Saharan African countries: a socio-cultural perspective, Globalization and Health, 5:10.
 
[9]  Zimbabwe Country Report January-December 2014, (2015) Global AIDS Response Progress Report 2015 Follow-Up to the 2011 Political Declaration on HIV/AIDS: Intensifying our Efforts to Eliminate HIV/AIDS, Available http://www.unaids.org/sites/default/files/country/documents/ZWE_narrative_report_2015.pdf.
 
[10]  Feeney ER, Mallon PWG (2011) HIV and HAART-Associated Dyslipidemia, The Open Cardiovascular Medicine Journal, 5: 49-63.
 
[11]  Karari E, Manuthu EM, Lule GN (2008) Prevalence of dyslipidemia and dysglycaemia in HIV infected patients, East African Medical Journal, 85:10-7.
 
[12]  Yusuf S, on behalf of the PURE Investigators, (2013) PURE: Contrasting associations between risk factor burden, CVD incidence and mortality in high, middle and low income countries, Presentation at European Society of Cardiology Congress.
 
[13]  World Health Organization (2014) Zimbabwe: Coronary Heart Disease, Available @ http://www.worldlifeexpectancy.com/zimbabwe-coronary-heart-disease.
 
[14]  Zimbabwe Health and Demographics Survey 2010-2011. Available @ http://microdata.worldbank.org/index.php/catalog/1532.
 
[15]  Zimbabwe Map (2016) Available @ https://encrypted-tbn0.gstatic.com/images? q=tbn:ANd9GcTfgI8RwZqKpffv8P6oE4TkugD7hjCCVhAiTPBWypCm4NgVLKxT.
 
[16]  CIA-Factbook, Zimbabwe – Economy 2016 (2016) Available @ http://www.theodora.com/wfbcurrent/zimbabwe/zimbabwe_economy.html.
 
[17]  Trading Economics (2016) Zimbabwe Unemployment Rate, Available @ http://www.tradingeconomics.com/zimbabwe/unemployment-rate.
 
[18]  Zimbabwe National Statistics Agency (2016) Unemployment rate, Available @ http://www.zimstat.co.zw/.
 
[19]  Brenner, M. Harvey (1979) Influence of the Social Environment on Psychology: The Historical Perspective. In Stress and Mental Disorder, Barrett E Ed, Raven Press. New York.
 
[20]  World Bank (2016) Zimbabwe Population Growth Rate Chart, Available @ www.multpl.com/zimbabwe-population-growth-rate.
 
[21]  Index Mundi (2016) Zimbabwe Death Rates, Available @ http://www.indexmundi.com/g/g.aspx?c=zi&v=26.
 
[22]  Tibaijuka AK, UN Special Envoy on Human Settlements Issues in Zimbabwe (2005) Report of the Fact-Finding Mission to Zimbabwe to assess the Scope and Impact of Operation Murambatsvina.
 
[23]  Centers for Disease Control (1981) Pneumocystis pneumonia-Los Angeles. Morbidity and Mortality Weekly Report; 30:250-252.
 
[24]  World Bank (2014) Graphs of life expectancy at birth for some Sub-Saharan countries, Available @ https://www.pinterest.com/pin/189854940514689842/.
 
[25]  UNAIDS Report on the Global AIDS Epidemic (2012) Available @http://www.unaids.org/sites/default/files/en/media/unaids/contentassets/documents/epidemiology/2012/.
 
[26]  AIDS and TB Program/Zimbabwe Ministry of Health and Child Care/National AIDS Council (2013) Zimbabwe National HIV Estimates, Available @ http://www.nac.org.zw/sites/default/files/Zimbabwe-National-HIV-and%20AIDS-2013%20Estimates.doc.
 
[27]  Mahomva A, Greby S, Dube S, Mugurungi O, Hargrove J, Rosen D, Dehne K-L, Gregson S, St Louis M, Hader S (2006) HIV prevalence and trends from data in Zimbabwe, 1997–2004. Sexually Transmitted Infections. 2006; 82(Suppl 1): i42-i47.
 
[28]  National AIDS Council (2013) HIV and AIDS Statistics, Available @ http://www.nac.org.zw/category/tags/hiv-and-aids-statistics.
 
[29]  CDC National Prevention Information Network (2003) Determinants of survival following HIV-1 sero-conversion after the introduction of HAART, The Lancet Vol. 362, 1267-1274, Available @ http://www.thebody.com/content/art29375.html.
 
[30]  BBC News (1999) World: Africa AIDS drug trade dispute ends, Available @ http://news.bbc.co.uk/2/hi/africa/450942.stm.
 
[31]  Zimbabwe Ministry of Health and Child Care (2013) Guidelines for Antiretroviral Therapy for the Prevention and Treatment of HIV in Zimbabwe National Medicine and Therapeutics Policy Advisory Committee (NMTPAC) and the AIDS and TB Directorate.
 
[32]  The Henry J Kaiser Family Foundation (2015) The Global HIV/AIDS Epidemic, Available @ff.org/global-health-policy/fact-sheet/the-global-hivaids-epidemic/.
 
[33]  Chastain DB, Henderson H, Stover KR (2015) Epidemiology and Management of Antiretroviral-Associated Cardiovascular Disease, Open AIDS J; 9: 23-37.
 
[34]  Sliwa K, Carrington MJ, Becker A, Thienemann F, Ntsekhe M, Stewart S (2011) Contribution of the human immunodeficiency virus/acquired immunodeficiency syndrome epidemic to de novo presentations of heart disease in the Heart of Soweto Study cohort.
 
[35]  Barbaro G, Rafael da Silva EF (2009) Cardiovascular complications in the acquired immunodeficiency syndrome, Rev Assoc Med Bras; 55:5.