American Journal of Medical and Biological Research
ISSN (Print): 2328-4080 ISSN (Online): 2328-4099 Website: http://www.sciepub.com/journal/ajmbr Editor-in-chief: Apply for this position
Open Access
Journal Browser
Go
American Journal of Medical and Biological Research. 2014, 2(6), 124-127
DOI: 10.12691/ajmbr-2-6-2
Open AccessArticle

Hepatoprotective Activity of Ethanol Extract of Conyza bonariensis against Paracetamol Induced Hepatotoxicity in Swiss Albino Mice

Mohammad Saleem1, , Faiza Naseer1, Sohail Ahmad2, Attiya Nazish1, Fiza Raza Bukhari1, Atta Ur Rehman1, Imran Mahmood Khan3, Samra Sadiq1 and Fatima Javed1

1College of Pharmacy, GC University, Faisalabad, Pakistan

2Department of Biochemistry, Hazara University, Mansehra, KPK, Pakistan

3Department of Pharmacology, Independent University Hospital, Faisalabad, Pakistan

Pub. Date: December 28, 2014

Cite this paper:
Mohammad Saleem, Faiza Naseer, Sohail Ahmad, Attiya Nazish, Fiza Raza Bukhari, Atta Ur Rehman, Imran Mahmood Khan, Samra Sadiq and Fatima Javed. Hepatoprotective Activity of Ethanol Extract of Conyza bonariensis against Paracetamol Induced Hepatotoxicity in Swiss Albino Mice. American Journal of Medical and Biological Research. 2014; 2(6):124-127. doi: 10.12691/ajmbr-2-6-2

Abstract

The hepatoprotective activity of Conyza bonariensis ethanol extract was studied against paracetamol induced hepatotoxicity in mice. The results showed that an extract of C.B (250 mg/kg and 500 mg/kg) produced (p<0.05) decline in paracetamol induced liver marker enzymes and total bilirubin, but its 750 mg/kg showed remarkable decline in ALT, AST, ALP and TB levels, compared to the reference levels of silymarin and results were supported by histopathology of liver section. So, it is concluded that 750 mg/kg is highly potent dose of ethanol extract of Conyza bonariensis and this potential may be due to the presence of the active constituent: qurecetin and chromatogram by HPLC confirmed its presence.

Keywords:
Conyza bonariensis hepatoprotective Paracetamol

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Figures

Figure of 2

References:

[1]  Ahmad S. Medicinal wild plants from Lahore-Islamabad motorway (M-2). Pak J Bot. 2007; 39: 355-75.
 
[2]  Ali M, Qadir MI, Saleem M, Janbaz KH, Gul H, Hussain L, Ahmad B. Hepatoprotective potential of Convolvulus arvensis against paracetamol-induced hepatotoxicity. Bangladesh J Pharmacol. 2013; 8: 300-04.
 
[3]  Bag AK, Mumtaz SMF. Hepatoprotective and nephroprotec-tive activity of hydroalcoholic extract OfIpomoea staphylina leaves. Bangladesh J Pharmacol. 2013; 8: 263-68.
 
[4]  Chaudhry A, Janbaz KH, Uzair M, Ejaz AS. Biological Studies of Conyza and Euphorbia species. J Res (Sci). 2001; 12 (1): 85-88.
 
[5]  Favila C, Antonio M. Chemical and Biological Study of Conyza bonariensis (L.) Cronquist (Asteraceae), Thesis dissertation. 2006.
 
[6]  Hegde K, Joshi AB. Hepatoprotective and antioxidant effect of Carissa spinarum root extract against CCl4 and paracetamol-induced hepatic damage in rats. Bangladesh J Pharmacol. 2010; 5: 73-76.
 
[7]  Khan RA, Bukhari IA, Nawaz SA, Choudhary MI. Acetylcholinesterase and butyrylcholinesterase inhibitory potential of some Pakistani medicinal plants. J Basic Appl Sci 2006; 2: 07-10.
 
[8]  Mallhi TH, Abbas K, Ali M, Qadir MI, Saleem M, Khan YH. Hepatoprotective activity of methanolic extract of Malva parviflora against paracetamol-induced hepatotoxicity in mice. Bangladesh J Pharmacol. 2014; 9: 00-00.
 
[9]  Qadir MI, Murad MSA, Ali M, Saleem M, Farooqi AA. Hepatoprotective effect of leaves of aqueous ethanol extract of Cestrum nocturnum against paracetamol-induced hepatotoxicity. Bangladesh J Pharmacol. 2014; 9: 167-70.
 
[10]  Rates SM. Plants as source of drugs. Toxicon. 2001; 39: 603-13.
 
[11]  Saleem M, Ahmed B, Qadir MI, Rafiq M, Ahmad M, Ahmad B. Hepatoprotective effect of Chenopodium murale in mice. Bang J Pharmacol. 2014; 9: 124-28.
 
[12]  Saleem M, Chetty M, Ramkanth S, Rajan V, Kumar MK, Gauthaman K. Hepatoprotective Herbs-A Review. Int. J. Res. Pharm. Sci. 2010; 1: 01-05.
 
[13]  Saleem M, Naseer F. Medicinal plants in the protection and treatment of liver diseases. Bangladesh J Pharmacol. 2014; 10: 511-526.
 
[14]  Santana PM, Miranda M, Gutiérrez Y, García G, Orellana T, Orellana-Manzano A. Anti-inflammatory and antimitotic effect of the alcoholic extract and chemical composition of the oil from Conyza bonariensis (L.) Cronquist (deer shinbone) leaves. Rev Cubana Plant Med. 2011; 16: 13-23.
 
[15]  Shahwar D, Raza MA, Saeed A, Riasat M, Chattha F, Javaid M, Ullah S, Ullah S. Antioxidant potential of the extracts of Putranjiva roxburghii, Conyza bonariensis, Woodfordia fruiticosa and Senecio chrysanthemoids. African Journal of Biotechnology. 2012; 11: 4288-95.
 
[16]  Valan MF, Brittob AJ, Venkataramanc R A Brief Review-Phytoconstituents With Hepatoprotective Activity. Int J Chem Sci 2010; 8: 1421-32.
 
[17]  Zahoor A, Hussain H, Khan A, Ahmed I, Ahmad V, Krohn K. Chemical Constituents from Erigeron bonariensis L. and their Chemotaxonomic Importance. Rec Nat. Prod. 2012; 6: 376-80.
 
[18]  Zalabani S, Hetta M, Ismail A. Genetic Profiling, Chemical Characterization and Biological. Evaluation of Two Conyza Species Growing in Egypt. J App Pharmaceut Sci. 2012; 2: 54-61.