Hepatoprotective Activity of Ethanol Extract of Conyza bonariensis against Paracetamol Induced Hepatotoxicity in Swiss Albino Mice

Mohammad Saleem^1, , Faiza Naseer¹, Sohail Ahmad², Attiya Nazish¹, Fiza Raza Bukhari¹, Atta Ur Rehman¹, Imran Mahmood Khan³, Samra Sadiq¹ and Fatima Javed¹

¹College of Pharmacy, GC University, Faisalabad, Pakistan

²Department of Biochemistry, Hazara University, Mansehra, KPK, Pakistan

³Department of Pharmacology, Independent University Hospital, Faisalabad, Pakistan

Cite this paper:
Mohammad Saleem, Faiza Naseer, Sohail Ahmad, Attiya Nazish, Fiza Raza Bukhari, Atta Ur Rehman, Imran Mahmood Khan, Samra Sadiq and Fatima Javed. Hepatoprotective Activity of Ethanol Extract of Conyza bonariensis against Paracetamol Induced Hepatotoxicity in Swiss Albino Mice. American Journal of Medical and Biological Research. 2014; 2(6):124-127. doi: 10.12691/ajmbr-2-6-2

Abstract

The hepatoprotective activity of Conyza bonariensis ethanol extract was studied against paracetamol induced hepatotoxicity in mice. The results showed that an extract of C.B (250 mg/kg and 500 mg/kg) produced (p<0.05) decline in paracetamol induced liver marker enzymes and total bilirubin, but its 750 mg/kg showed remarkable decline in ALT, AST, ALP and TB levels, compared to the reference levels of silymarin and results were supported by histopathology of liver section. So, it is concluded that 750 mg/kg is highly potent dose of ethanol extract of Conyza bonariensis and this potential may be due to the presence of the active constituent: qurecetin and chromatogram by HPLC confirmed its presence.

Keywords:
Conyza bonariensis hepatoprotective Paracetamol

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