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American Journal of Medical and Biological Research. 2014, 2(6), 124-127
DOI: 10.12691/ajmbr-2-6-2
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Hepatoprotective Activity of Ethanol Extract of Conyza bonariensis against Paracetamol Induced Hepatotoxicity in Swiss Albino Mice

Mohammad Saleem1, , Faiza Naseer1, Sohail Ahmad2, Attiya Nazish1, Fiza Raza Bukhari1, Atta Ur Rehman1, Imran Mahmood Khan3, Samra Sadiq1 and Fatima Javed1

1College of Pharmacy, GC University, Faisalabad, Pakistan

2Department of Biochemistry, Hazara University, Mansehra, KPK, Pakistan

3Department of Pharmacology, Independent University Hospital, Faisalabad, Pakistan

Pub. Date: December 28, 2014

Cite this paper:
Mohammad Saleem, Faiza Naseer, Sohail Ahmad, Attiya Nazish, Fiza Raza Bukhari, Atta Ur Rehman, Imran Mahmood Khan, Samra Sadiq and Fatima Javed. Hepatoprotective Activity of Ethanol Extract of Conyza bonariensis against Paracetamol Induced Hepatotoxicity in Swiss Albino Mice. American Journal of Medical and Biological Research. 2014; 2(6):124-127. doi: 10.12691/ajmbr-2-6-2


The hepatoprotective activity of Conyza bonariensis ethanol extract was studied against paracetamol induced hepatotoxicity in mice. The results showed that an extract of C.B (250 mg/kg and 500 mg/kg) produced (p<0.05) decline in paracetamol induced liver marker enzymes and total bilirubin, but its 750 mg/kg showed remarkable decline in ALT, AST, ALP and TB levels, compared to the reference levels of silymarin and results were supported by histopathology of liver section. So, it is concluded that 750 mg/kg is highly potent dose of ethanol extract of Conyza bonariensis and this potential may be due to the presence of the active constituent: qurecetin and chromatogram by HPLC confirmed its presence.

Conyza bonariensis hepatoprotective Paracetamol

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