American Journal of Medical and Biological Research
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American Journal of Medical and Biological Research. 2014, 2(4), 97-100
DOI: 10.12691/ajmbr-2-4-3
Open AccessArticle

Presepsin: A Novel and Potential Diagnostic Biomarker for Sepsis

K V Ramana1, , Venkata BharatKumar Pinnelli2, Sabitha Kandi3, Asha G2, Jayashankar CA4, Bhanuprakash5, Raghavendra DS2 and Sanjeev D rao1

1Department of Microbiology, Prathima Institute of Medical sciences, Karimnagar, India

2Department of Biochemistry, Vydehi Institute of Medical sciences and Research center, Bengaluru, India

3Department of Biochemistry, Chalmeda Anandarao Institute of Medical sciences, Karimnagar, India

4Department of General Medicine, Vydehi Institute of Medical sciences and Research center, Bengaluru, India

5Department of Dermatology, Vydehi Institute of Medical sciences and Research center, Bengaluru, India

Pub. Date: October 19, 2014

Cite this paper:
K V Ramana, Venkata BharatKumar Pinnelli, Sabitha Kandi, Asha G, Jayashankar CA, Bhanuprakash, Raghavendra DS and Sanjeev D rao. Presepsin: A Novel and Potential Diagnostic Biomarker for Sepsis. American Journal of Medical and Biological Research. 2014; 2(4):97-100. doi: 10.12691/ajmbr-2-4-3

Abstract

Sepsis is a potential clinical condition which is a consequence of infectious disease or a severe inflammatory reaction secondary to infection or injury. Sepsis in Greek means putrefaction or decay, correlating well with the multiple organ failure and severe shock resulting in death of the patient suffering from severe sepsis. Clinical management of sepsis requires prompt laboratory diagnosis and formulation of effective patient management strategies that may include antimicrobial chemotherapy in case of sepsis induced by infectious microbe. Although many laboratory biomarkers are available for the diagnosis of sepsis, only few markers have proven to be beneficial in differentiating infectious disease sepsis and sepsis of non-infectious origin. Of the available markers only few have prognostic value. We in this review discuss the utility of a novel and emerging sepsis marker, the presepsin which has a better diagnostic and prognostic value, and has been effective in predicting the survival of the sepsis patients.

Keywords:
presepsin sepsis marker management of sepsis

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