American Journal of Medical and Biological Research
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American Journal of Medical and Biological Research. 2021, 9(1), 5-9
DOI: 10.12691/ajmbr-9-1-2
Open AccessArticle

Correlation between Free Testosterone and Severity of Coronary Artery Disease in Young Adult Male Patients

Amit Kumar Pramanik1, , Shihab Md. Rezoyanur Rahman2, Kaniz Fatema3, Mohammad Monzurul Alam Bhuiyan4, Sheuly Ferdoushi4, Mst. Shaila Yesmin4, Md. Saiful Islam4, Md. Quddusur Rahman4, Shaikh Nafia Sultana5 and Debatosh Paul4

1Department of Transfusion Medicine, Rajshahi Medical College Hospital, Rajshahi, Bangladesh

2Gaibandha General Hospital, Gaibandha, Bangladesh

3Sheikh Hasina National Institute of Burn and Plastic Surgery, Dhaka, Bangladesh

4Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh

5Department of Urology, United Hospital, Dhaka, Bangladesh

Pub. Date: September 13, 2021

Cite this paper:
Amit Kumar Pramanik, Shihab Md. Rezoyanur Rahman, Kaniz Fatema, Mohammad Monzurul Alam Bhuiyan, Sheuly Ferdoushi, Mst. Shaila Yesmin, Md. Saiful Islam, Md. Quddusur Rahman, Shaikh Nafia Sultana and Debatosh Paul. Correlation between Free Testosterone and Severity of Coronary Artery Disease in Young Adult Male Patients. American Journal of Medical and Biological Research. 2021; 9(1):5-9. doi: 10.12691/ajmbr-9-1-2

Abstract

Historically, High level of serum testosterone was thought to have deleterious effect on cardiovascular system. In the last few years, studies have suggested that low testosterone levels are associated with increase prevalence of risk factors for cardiovascular diseases. This study aimed to determine the relationship between free testosterone level and the angiographic severity of coronary artery disease in young adult male patients. This cross-sectional study was conducted at Department of Laboratory Medicine in collaboration with Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU) and National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh from March, 2020 to February, 2021. Total 110 subjects from inpatient Department of Cardiology were enrolled, 60 were CAD patients and 50 were Normal Coronaries according to coronary angiography report. Serum level of free testosterone was significantly lower in CAD group than Normal coronaries (4.74±2.10 vs 9.36±3.69 pg/ml, p=0.001). There were significant negative correlation between free testosterone with Gensini score (r= -0.739, p=0.001). Low level of free testosterone was negatively correlated with CAD and its severity in young adult male.

Keywords:
Coronary artery diseases Gensini score free testosterone young adult male

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