American Journal of Medical and Biological Research
ISSN (Print): 2328-4080 ISSN (Online): 2328-4099 Website: Editor-in-chief: Apply for this position
Open Access
Journal Browser
American Journal of Medical and Biological Research. 2019, 7(1), 20-23
DOI: 10.12691/ajmbr-7-1-4
Open AccessArticle

Comparison of Vasculosyncytial Membrane Thickness at Different Gestational Periods

Md. Ashraful Azim1, , Mohammad Ashfaqur Rahman1 and Farhana Karim2

1Department of Anatomy, Ad-din Akij Medical College, Khulna, Bangladesh

2Department of Paediatrics, Ad-din Akij Medical College, Khulna, Bangladesh

Pub. Date: October 22, 2019

Cite this paper:
Md. Ashraful Azim, Mohammad Ashfaqur Rahman and Farhana Karim. Comparison of Vasculosyncytial Membrane Thickness at Different Gestational Periods. American Journal of Medical and Biological Research. 2019; 7(1):20-23. doi: 10.12691/ajmbr-7-1-4


Vasculosyncytial membrane is the only structural barrier between maternal and fetal circulation found in the wall of the terminal chorionic villi. Its normal function is essential for the survivability of a growing fetus. Understand the role of the placenta during fetal growth; it is necessary to know changes of vasculosyncytial membrane with gestational age. This study carried out on total ninety products of conception and placenta, and all the collected samples divided into three groups. One group included 30 products of conception from the first-trimester pregnant woman, and another two groups included a total of 60 placentae from the second and third-trimester pregnant woman. All the placentae were fixed in 10% formol saline for 48 hours, after fixation two tissue blocks taken from each specimen. After tissue processing and staining, the histomorphological changes studied among three groups under the light microscope — statistical analysis done by ANOVA test. In the first-trimester placenta, vasculosyncytial membrane was absent. In the second trimester, it ranged from 5.1 – 15.00 μm and the mean ± SD was 8.54 ± 0.84 μm. In the third trimester, it ranged from 1.90 – 4.70 μm, and the mean ± SD was 3.12 ± 0.73 μm. Vasculosyncytial membrane thickness significantly reduced with the aging of the placenta. The study findings suggest placental tissue continued to grow until term. Rate of exchange of gas and other nutrients supposed to be more with the advancement of pregnancy.

vasculosyncytial membrane chorionic villi diffusion distance placenta

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit


[1]  Sadler, T.W., Langman’s Medical Embryology, Lippincott Willliam and Wilkins, Philadelphia, 2012, 59-61.
[2]  Carlson, B.M., Human Embryology and Developmental Biology, Saunders, Philadelphia, 2014.
[3]  Griffiths, S.K. and Campbell, J.P., 2015. “Placental structure, function and drug transfer,” Continuing Education in Anaesthesia, Critical Care & Pain, 15(2). 84-89. April 2015.
[4]  Sanker, K.D., et al., “Vasculosyncytial membrane in relation to syncytial knot complicates the placenta in preeclampsia: a histomorphometrical study,” Anatomy and Cell Biology, 45(2). 86-91. Jun. 2012.
[5]  Burton, G.J. Charnock- Jones, D.S. and Jauniaux, E., “Regulation of vascular growth and function in the human placenta,” Reproduction, 138 (6), 895-902, Dec.2009.
[6]  Baergen, R.N., Manual of Benirschke and Kaufmann’s Pathology of the Human Placenta, Springer, New York, 2005.
[7]  Wong, T. and Latour, J.P.A., “Microscopic measurement of the placental components in an attempt to assess the malnourished newborn infant” American journal of Obstetrics and Gynaecology, 94(7), 942-950, April. 1966.
[8]  Saeed, I., et al., “Histomorphological changes in placentae of pre-eclamptic mothers with reference to vasculosyncytial membrane thickness and syncytial knot formation” Journal of Rawalpindi Medical College, 16(1). 51-54. 2012.