Advantages of Alternate Biomarkers in the Management of Human Immunodeficiency Virus with Highly Active Antiretroviral Therapy

Venkataramana Kandi^1, and Adnan Bashir Bhatti²

¹Prathima Inst. of Medical Sciences, Karimnagar, Telangana, India

²Department of Medicine, Capital Development Authority Hospital, Islamabad, Pakistan

Cite this paper:
Venkataramana Kandi and Adnan Bashir Bhatti. Advantages of Alternate Biomarkers in the Management of Human Immunodeficiency Virus with Highly Active Antiretroviral Therapy. American Journal of Infectious Diseases and Microbiology. 2016; 4(2):32-34. doi: 10.12691/ajidm-4-2-2

Abstract

The disease burden of human immunodeficiency virus (HIV) is substantially more prevalent among residents of the sub-Saharan Africa and Asia. The availability and affordability of highly active antiretroviral therapy (HAART) have significantly reduced the mortality among HIV-1 infected population, increase their life expectancy and quality of life. However, the poor financial conditions and lack of costly infrastructure in the developing countries hinder regular monitoring of HIV-1 RNA (viral load) and CD4+ T-lymphocyte cell count (TCD4+ cell count). Under these circumstances, there is an increasing need for alternate biomarkers for monitoring the progression of the disease and patient management. Albumin, hemoglobin (Hb), dehydroepiandrosterone sulfate (DHEA-S), red blood cell (RBC) count, erythrocyte sedimentation rate (ESR), plasma highly-sensitive C-reactive protein (hs-CRP), hematocrit (Hct), total lymphocyte count (TLC) are some of the alternate biomarkers with proven utility in the assessment of disease progression.

Keywords:
human immunodeficiency virus highly active antiretroviral therapy alternate biomarkers HIV disease progression

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