American Journal of Infectious Diseases and Microbiology
ISSN (Print): 2328-4056 ISSN (Online): 2328-4064 Website: Editor-in-chief: Maysaa El Sayed Zaki
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American Journal of Infectious Diseases and Microbiology. 2022, 10(4), 131-138
DOI: 10.12691/ajidm-10-4-3
Open AccessArticle

First Detection of Fluoroquinolones and Aminoglycosides Resistance Genes in Multiresistant Enterobacteriaceae from Urinary Tract Infections

Nicole Prisca Makaya Dangui Nieko1, 2, , Cyr Jonas Morabandza1, 3, Moїse Doria Kaya-Ongoto1, 4, Duchel Jeanedvi Kinouani Kinavouidi1, 4 and Prosvi-Esrom Bikouma Mbangou2

1Service de Bactériologie, Laboratoire National de Santé Publique, BP 120, Brazzaville, Congo

2Ecole Normale Supérieure, Université Marien Ngouabi, BP 69, Brazzaville, Congo

3Ecole Normale Supérieure, Université Marien Ngouabi, BP 69, Brazzaville, Congo;Faculté des Sciences et Techniques, Université Marien Ngouabi, BP 69, Brazzaville, Congo

4Faculté des Sciences et Techniques, Université Marien Ngouabi, BP 69, Brazzaville, Congo

Pub. Date: December 21, 2022

Cite this paper:
Nicole Prisca Makaya Dangui Nieko, Cyr Jonas Morabandza, Moїse Doria Kaya-Ongoto, Duchel Jeanedvi Kinouani Kinavouidi and Prosvi-Esrom Bikouma Mbangou. First Detection of Fluoroquinolones and Aminoglycosides Resistance Genes in Multiresistant Enterobacteriaceae from Urinary Tract Infections. American Journal of Infectious Diseases and Microbiology. 2022; 10(4):131-138. doi: 10.12691/ajidm-10-4-3


Aminoglycosides and fluoroquinolones are among the most used antibiotics in synergy with beta-lactams. The objective of this work was to detect genes associated with resistance to fluoroquinolones and aminoglycosides in multiresistant strains of enterobacteria responsible for urinary tract infections. The diffusion method was used for antimicrobial sensitivity test of strains. qnr and aac genes were detected by Polymerase Chain Reaction. A total of 128 enterobacterial strains were studied. Resistance to the antibiotic families tested was observed with a frequency greater than 50%. Aminoglycosides were the least active family among the antibiotics used, with a resistance rate of 69.53%. aac(6’)-Ib-cr and qnrS genes were detected at rates of 34.09% and 22.72%, respectively. 13.63% of the strains showed coexpression of the qnr and aac genes. The detection of resistance genes to fluoroquinolones and aminoglycosides in enterobacterial strains isolated at the National Public Health Laboratory in Brazzaville could constitute a major concern in the therapeutic management of patients because it could lead to high costs for prolonged hospitalization.

Enterobacteriaceae multidrug resistance fluoroquinolones and aminoglycosides resistance genes urinary tract infections

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