American Journal of Infectious Diseases and Microbiology
ISSN (Print): 2328-4056 ISSN (Online): 2328-4064 Website: http://www.sciepub.com/journal/ajidm Editor-in-chief: Maysaa El Sayed Zaki
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American Journal of Infectious Diseases and Microbiology. 2014, 2(1), 11-16
DOI: 10.12691/ajidm-2-1-3
Open AccessReview Article

Altercating Leishmaniasis: Cultivating Improved Vaccines

Neha Dhingra1 and Sandeep Satapathy2,

1Department of Zoology, University of Delhi, Delhi, India

2Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India

Pub. Date: January 06, 2014

Cite this paper:
Neha Dhingra and Sandeep Satapathy. Altercating Leishmaniasis: Cultivating Improved Vaccines. American Journal of Infectious Diseases and Microbiology. 2014; 2(1):11-16. doi: 10.12691/ajidm-2-1-3

Abstract

The exponentially rising cases of Leishmaniasis over the past decades, has attracted scientists and clinicians to mitigate the contagious infection by modern treatments and new generation vaccinations. Leishmania, the causative pathogen of this infection predominantly expresses its diseased condition in form of cutaneous leishmaniasis. Although systemic leishmaniasis, is a more deadly form, but cases of its manifestation are limited; thereby staging the focus onto more intricate study of cutaneous leishmaniasis. Designing a vaccine against Leishmania has witnessed more than two generations of vaccine, but each attempt has failed more than it’s cases of success. The proposed drawbacks root to the difficulty in ensuring an efficient transition of research from simple laboratory experiments carried out in-vitro/in-vivo in small animals to that of the humans. There have been extensive case studies of this disease and thus every immunological aspect has been our focus. This paper is an attempt to decipher the ideas and methodologies adopted till date and further target the genetic spans and molecular moieties, for crafting an alternative vaccine based on efforts to mock the pathogenic pathways.

Keywords:
cutaneous proteomics recombinant DNA macrophage life cycle live-attenuated vaccines

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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