Antioxidant Potential of Stem Bark Extract of Shorea roxburghii against CCl₄ induced Liver Damage in Wistar Rats

V. Menakapriya¹, K. Karthikarathi¹, R. Subramanian^{1, 2,} , A. Kathirvel¹ and V. Raj³

¹Department of Chemistry, K.S. Rangasamy College of Arts and Science, Tiruchengode, Tamilnadu, India

²Department of Chemistry, Sun Arts and Science College, Tiruvannamalai, Tamilnadu, India

³Department of Chemistry, Periyar University, Salem, Tamilnadu, India

Cite this paper:
V. Menakapriya, K. Karthikarathi, R. Subramanian, A. Kathirvel and V. Raj. Antioxidant Potential of Stem Bark Extract of Shorea roxburghii against CCl₄ induced Liver Damage in Wistar Rats. American Journal of Food and Nutrition. 2017; 5(4):121-125. doi: 10.12691/ajfn-5-4-2

Abstract

The aim of the present study was to evaluate the antioxidant potential of the stem bark extract of Shorea roxburghii (S. roxburghii) on CCl₄ induced liver toxicity. Stem bark extract of Shorea roxburghii (SRE) was prepared using ethyl acetate. Administration of S. roxburghii inhibited the elevation marker enzymes such as aminotransferase (AST), alkaline phosphatase (ALP) and alanine aminotransferase (ALT) and liver lipid peroxides in CCl₄-treated Wistar rats. The natural antioxidant enzymes such catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) and lipid peroxidation were significantly improved after the treatment of S.roxburghii. In this study, the results indicate that S.roxburghii can inhibit lipid peroxidation and improve the activities of antioxidant enzymes. The quantitative analysis of biochemical parameters, marker enzymes, antioxidant activities and histological study suggest the administration of the stem bark extract of S.roxburghii protecting the liver from CCl₄ toxicity.

Keywords:
antioxidant activity Shorea roxburghii liver liver markers CCl₄ toxicity

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