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American Journal of Epidemiology and Infectious Disease. 2016, 4(1), 1-9
DOI: 10.12691/ajeid-4-1-1
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Multiple Sclerosis in Cyprus: A Fourteen Year (2000-2014) Epidemiological Study

Elena Charalambidou1, Marios Pantzaris2 and Ioannis Patrikios2, 3,

1European University Cyprus, Department of Health and Science Nicosia, Cyprus

2The Cyprus Institute of Neurology and Genetics, Clinic C, Nicosia, Cyprus

3European University Cyprus, School of Medicine, Nicosia, Cyprus

Pub. Date: January 21, 2016

Cite this paper:
Elena Charalambidou, Marios Pantzaris and Ioannis Patrikios. Multiple Sclerosis in Cyprus: A Fourteen Year (2000-2014) Epidemiological Study. American Journal of Epidemiology and Infectious Disease. 2016; 4(1):1-9. doi: 10.12691/ajeid-4-1-1


Background: Multiple Sclerosis (MS) is a complex, multifactorial, chronic disease resulting from the interplay between two major factors, environmental and genetic. Cyprus is one of the countries without real history on epidemiological information for the disease and without any records based on scientific evidence. Methods: The present study is a descriptive as well as a comparative study. We analyzed retrospectively the records of the MS patients admitted to the Cyprus Institute of Neurology and Genetics (CING), between the years 2000-2014. A total of 427 MS patients were studied that is the 25% of the total MS patients in Cyprus. Results: The estimated prevalence of Cyprus was 198:100,000, with the district of Famagusta associated with the highest prevalence (57:100,000). The male to female ratio was1.6:1 and the mean age during exacerbation of the disease was 37.4 for females and 38.7 for males. The distribution of incidents according to place of birth was not statistically significant (p = 0.152); but the distribution of incidents by place of residence at the time of diagnosis was statistically significant (p = 0.049). Family history had no any statistical significance (p=0.246). The majority of the patients (66.2%, p=0.038) reported to be married during the disease diagnosis and 22.5% were serious smokers (p=0.81).Moreover, 0.74% out of the primary progressive and 0.49% out of the secondary progressive patients died as a result of the disease. Conclusions: The prevalence was higher than the expected, higher than the official reported by the Atlas of MS 2013 and disproportional to the global median prevalence of 90/100,000.Parameters like profession and smoking habit had no significance versus the disease of MS.

multiple sclerosis MS incidence MS prevalence relapsing-remitting multifactorial autoimmune neurodegenerative

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[1]  Centers for Disease Control and Prevention.
[2]  Pantzaris C.M, Loukaides G.N, Ntzani E.E, Patrikios S.I; A novel oral nutraceutical formula of omega-3 and omega-6 fatty acids with vitamins (PLP10) in relapsing remitting multiple sclerosis: a randomized, double-blind, placebo-controlled proof-of-concept clinical trial BMJ Open 2013.
[3]  Sadovnick A.D,Dyment D,Ebers G.C; Genetic Epidemiology of multiple Sclerosis; Epidemiologic reviews, 1997, vol.19, No. 1: 99-106.
[4]  Aljumah M, Alroughani R, Alsharoqi I,; Future of Management of Multiple Sclerosis in the Middle East: A Consensus View from Specialists in Ten Countries; Multiple Sclerosis International, 2013, Article ID 952321.
[5]  Multiple sclerosis association of America;
[6]  Pugliatti M, Rosati G, Carton H, Riise T, Drulovic J, Vecsei L and Milanov I; The epidemiology of multiple sclerosis in Europe; European Journal of Neurology 2006,13:700-72.
[7]  Koutsouraki E, Fotakidou A, Kalatha T, Baloyannis S. Epidemiologic Data of Multiple Sclerosis in Northern Greece during the Last Thirty Years (1979-2008). American Journal of Epidemiology and Infectious Disease, 2013, Vol. 1, No. 1, 1-7.
[8]  Atlas of MS2013; multiple sclerosis international federation 2013.
[9]  Harbo H.F, Gold R, Tintore M; Sex and gender issues in Multiple Sclerosis.2013; 6(4):237-248.
[11]  Cleveland clinic, center of continuing education.
[12]  Hansen T, Skytthe A, Stenager E, et al.; Concordance for multiple sclerosis in Danish twins: an update of a nationwide study; MultScler 2005; 11:504-510.
[13]  Hernán M.A; Zhang S M; Lipworth L; Olek M J; Ascherio A; Multiple Sclerosis and Age at Infection with Common Viruses; May 2001, Volume 12;3:301-306.
[14]  Klaus Lauer; Notes on the Epidemiology of Multiple Sclerosis, with Special Reference to Dietary Habits; Int J MolSci; 2014 Mar; 15(3): 3533-3545.
[15]  Belbasis L, Bellou V, Evangelou E, Ioannidis J, Tzoulaki I; Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses; Lancet Neurol; 2015 Mar;14(3):263-73.
[16]  National search for proteins that cause MS; THE UNIVERSITY of ADELAIDE; Wednesday, 26 August 2009;
[17]  National Multiple sclerosis society;
[18]  Multiple Sclerosis; Patient;
[19]  Brichford C; Understanding the Different Types of Multiple sclerosis; everyday HEALTH;
[20]  Out of the unpublished library records of the Cyprus Institute of Neurology and Genetics (CING)
[21]  Filippini G, Del Giovane C, Vacchi L, D’Amico R, Di Pietrantonj C, Beecher D, Salanti G; Immunomodulators and immunosuppressants for multiple sclerosis: a network meta-analysis (Review); Cochrane reviews; The Cochrane Library; 2013; 6.
[22]  WebMD;
[23]  Unpublished data, personal communication, Dr Marios Pantzaris, CING.
[24]  Atlas of MS/ MS International Federation;
[25]  Wang YC, Meyerson L, Tang YQ, et al. Statistical methods for the analysis of relapse data in MS clinical trials. J NeurolSci; 2009; 285: 206-11.
[26]  Deshpande R, Kremenchutzky M, Rice G; The natural history of multiple sclerosis; Neurologic Clinics;1995;13:119-146.