American Journal of Epidemiology and Infectious Disease
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American Journal of Epidemiology and Infectious Disease. 2014, 2(4), 88-92
DOI: 10.12691/ajeid-2-4-1
Open AccessCase Study

Antibiotics Susceptibility Patterns of some Uropathogens to Nitrofurantoin and Nalidixic Acid among Pregnant Women with Urinary Tract Infections in Federal Medical Centre, Bida, Niger-State, North Central, Nigeria

Akobi Oliver Adeyemi1, , Emumwen Evbaziegbere Gideon1, Inyinbor Henry Eromosele1, Akobi Evelyn Chimerenma2, Ogedengbe Sunday Oladokun1, Uzoigwe Eunice Ogochukwu1, Abayomi Rachel Olufunmilayo1 and Emumwen Ehiosu Favour3

1Medical Microbiology Department, Federal Medical Centre, Bida, Niger-State

2Nursing Department, Federal Medical Centre, Bida, Niger State

3Medical Laboratory Services, Fed. Polytechnic Medical Centre, Bida, Niger-State

Pub. Date: August 10, 2014

Cite this paper:
Akobi Oliver Adeyemi, Emumwen Evbaziegbere Gideon, Inyinbor Henry Eromosele, Akobi Evelyn Chimerenma, Ogedengbe Sunday Oladokun, Uzoigwe Eunice Ogochukwu, Abayomi Rachel Olufunmilayo and Emumwen Ehiosu Favour. Antibiotics Susceptibility Patterns of some Uropathogens to Nitrofurantoin and Nalidixic Acid among Pregnant Women with Urinary Tract Infections in Federal Medical Centre, Bida, Niger-State, North Central, Nigeria. American Journal of Epidemiology and Infectious Disease. 2014; 2(4):88-92. doi: 10.12691/ajeid-2-4-1

Abstract

Background: Antimicrobial drug resistance is a worldwide problem that is exacerbated by the diminishing number of new antimicrobial drugs. Developing countries face substantial problems of antimicrobial resistance as a result of emerging and re-emerging resistant organisms. Aim: This study was design to reports on antibiotic susceptibility and resistance pattern of bacteria pathogens of UTIs among pregnant women in Bida, North Central, Nigeria, and to determine the extent of resistance of these bacteria pathogens to these drugs in the community. Materials and Methods: The research was a retrospective studies carried out between August 2012 to December 2013 and were exempted from ethical approval. Five hundred and sixteen (516) bacterial pathogens were selected for this study as isolated at the Medical Microbiology Department of Federal Medical Centre, Bida, Niger State, North Central, Nigeria. Data was coded, computed and analyzed using SPSS version 16.0 and p-values ≤0.05 was considered to be statistically significant. Result: Out of this 516 bacteria isolates, Escherichia coli 342(66.3%) was the most predominant followed by Staphylococcus aureus 162(31.4%), Klebsiella specie 6(1.2%), Serratia marcescens 4(0.8%) and the least prevalence Proteus specie 2(0.4%). Overall susceptibility pattern of uropathogens to Nitrofurantoin was (58.5%) and Nalidixic acid (34.5%) and both were statistically significant (Nitrofurantoin p=0.000, Mean value 75.5 and Nalidixic acid p=0.000, Mean value 44.5). Escherichia coli the highest in predominance shows susceptibility rate of 61.4% and 42.1% to Nitrofurantoin and Nalidixic acid respectively. Conclusion: Routine microbiological analysis and susceptibility test should be carried out before administration of drugs to patient. Government should make policy that will discourage over the counter sales and use of antimicrobials without prescription from authorized Medical personnel.

Keywords:
Antibiotics susceptibility Uropathogen Urinary tract infections

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