American Journal of Cancer Prevention
ISSN (Print): 2328-7314 ISSN (Online): 2328-7322 Website: Editor-in-chief: Nabil Abdel-Hamid
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American Journal of Cancer Prevention. 2018, 6(2), 24-28
DOI: 10.12691/ajcp-6-2-2
Open AccessCase Report

Follicular Carcinoma of Thyroid with the First Presentation as Vertebral Column Metastasis: A Case-report

Mazaher Ramezani1, Kaivan Mohammadi2 and Masoud Sadeghi3,

1Molecular Pathology Research Center, Emam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Pub. Date: March 30, 2018

Cite this paper:
Mazaher Ramezani, Kaivan Mohammadi and Masoud Sadeghi. Follicular Carcinoma of Thyroid with the First Presentation as Vertebral Column Metastasis: A Case-report. American Journal of Cancer Prevention. 2018; 6(2):24-28. doi: 10.12691/ajcp-6-2-2


Follicular carcinoma of thyroid is the second most common type of thyroid cancer that its incidence has increased in recent years. Herein, the study reported a 64-year male case of follicular carcinoma of thyroid that his first presentation was vertebral column metastasis. His chief complaint was back pain. In the past medical history, the patient had hypothyroidism and was opium inhalation addict since 15 years ago. Thoraco-lumbar magnetic resonance imaging (MRI) demonstrated spinal tumor of T10. The pathology report showed metastatic follicular carcinoma of thyroid with Thyroid transcription factor-1 (TTF-1), Thyroglobulin (TG), and Cytokeratin-7 (CK-7) positivity. Then thyroidectomy confirmed the diagnosis. In conclusion, follicular carcinoma of thyroid may be presented with spinal column metastasis. Pathologist should consider this diagnosis in the differential diagnosis of metastatic carcinoma in vertebral column and use Thyroglobulin with TTF-1 in immunohistochemistry panel for definite diagnosis and identification of origin.

follicular carcinoma thyroid metastasis case report

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