American Journal of Cancer Prevention
ISSN (Print): 2328-7314 ISSN (Online): 2328-7322 Website: Editor-in-chief: Nabil Abdel-Hamid
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American Journal of Cancer Prevention. 2018, 6(2), 20-23
DOI: 10.12691/ajcp-6-2-1
Open AccessCase Report

Dermatologic Manifestations and Pulmonary Involvement in Two Patients with Hypereosinophilic Syndrome - A Case Series

Mehrdad Payandeh1, Afshin Karami2, , Noorodin Karami3, Mehrnoosh Aeinfar1, Fatemeh Feizi2, Amir Yami2, Akram Sourni4 and Hedieh Heidary4

1Department of Hematology and Medical Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Department of Hematology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Department of Genetics, Shahid Sadoughi University of Medical Science, Yazd, Iran

4Department of Nursing, Kermanshah University of Medical Sciences, Kermanshah, Iran

Pub. Date: March 23, 2018

Cite this paper:
Mehrdad Payandeh, Afshin Karami, Noorodin Karami, Mehrnoosh Aeinfar, Fatemeh Feizi, Amir Yami, Akram Sourni and Hedieh Heidary. Dermatologic Manifestations and Pulmonary Involvement in Two Patients with Hypereosinophilic Syndrome - A Case Series. American Journal of Cancer Prevention. 2018; 6(2):20-23. doi: 10.12691/ajcp-6-2-1


Hypereosinophilic syndrome is a group of disorders described by excessive production of eosinophils, their infiltration and the release of mediators that cause damage to multiple organs. Two patients of 67 and 38 years old, were referred to the clinic of Hematology and Oncology, Kermanshah, Iran, in 2016 and 2017, respectively. In the first case, there was no suspicious item in the patient's medical records and his most prominent features were pulmonary emphysema, and hypopigmented lesions, while in the second case, in addition to having a history of asthma, lesions of eczema were also seen. Hence, according to these characteristics and the results of the tests performed, our differential diagnosis was the Hypereosinophilic syndrome. We started the treatment with two types of drugs, Imatinib and Prednisolone. The treatment of patients is still ongoing and their condition was relatively promising.

hypereosinophilic syndrome pulmonary emphysema eczema imatinib

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