American Journal of Cancer Prevention
ISSN (Print): 2328-7314 ISSN (Online): 2328-7322 Website: Editor-in-chief: Nabil Abdel-Hamid
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American Journal of Cancer Prevention. 2017, 5(2), 25-27
DOI: 10.12691/ajcp-5-2-2
Open AccessCase Report

Multilocular Cystic Nephroma in a Child: A Rare Case

Mazaher Ramezani1, Maryam Mirzaei1, Mahya Alsadat Bagheri Mousavi2 and Masoud Sadeghi3,

1Molecular Pathology Research Center, Emam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Pub. Date: April 13, 2017

Cite this paper:
Mazaher Ramezani, Maryam Mirzaei, Mahya Alsadat Bagheri Mousavi and Masoud Sadeghi. Multilocular Cystic Nephroma in a Child: A Rare Case. American Journal of Cancer Prevention. 2017; 5(2):25-27. doi: 10.12691/ajcp-5-2-2


Multilocular cystic nephroma (MLCN) is classically described as a benign slow-growing renal tumor. The aim of this study was to evaluate MLCN in a child in the West of Iran. The ultrasound examination showed a multicystic mass measuring 6.6x6.5 cm with multiple internal septae in the middle and lower left kidney in a 19-month-old boy. Another sonography revealed multicystic mass 7.4x6.6cm in left renal pole with a diagnosis of multicystic nephroma. The lab data were within normal limits, except for hemoglobin level, that was 11.6 g/dl. The gross examination revealed kidney tissue measuring 10x8x7 cm including multiloculated cyst measuring up to 8 cm and the microscopic examination revealed multiple cysts lined by flat epithelium with spindle cell stroma containing abortive tubular elements and rare foci of small round cells. In conclusion, MLCN occures more in male children and female adults. The results showed that low hemoglobin level had association with some cases of MLCN. Inflammation may be seen in MLCN, but presence of any amount of blastemal cells is diagnosed as cystic partially differentiated nephroblastoma by most experts.

Multilocular cystic nephroma children case report

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[1]  Stamatiou K, Polizois K, Kollaitis G, Dahanis S, Zafeiropoulos G, Leventis C, et al. Cystic nephroma: a case report and review of the literature. Cases J. 2008; 1(1): 267.
[2]  Granja MF, O'Brien AT, Trujillo S, Mancera J, Aguirre DA. Multilocular Cystic Nephroma: A Systematic Literature Review of the Radiologic and Clinical Findings. AJR Am J Roentgenol. 2015; 205(6): 1188-93.
[3]  Dong B, Wang Y, Zhang J, Fu Y, Wang G. Multilocular cystic nephroma treated with laparoscopic nephron-sparing surgery: A case report. Can Urol Assoc J. 2014; 8(7-8): E545-7.
[4]  Ceglia M, Galliani CA, Senger C, Stallone C, Sessa A. Renal cystic diseases: A review. Adv Anat Pathol. 2006; 13(1): 26-56.
[5]  Wilkinson C, Palit V, Bardapure M, Thomas J, Browning AJ, Gill K, et al. Adult multilocular cystic nephroma: Report of six cases with clinical, radio-pathologic correlation and review of literature. Urol Ann. 2013; 5(1): 13-7.
[6]  Madewell JE, Goldman SM, Davis CJ Jr, Hartman DS, Feigin DS, Lichtenstein JE. Multilocular cystic nephroma: a radiographic-pathologic correlation of 58 patients. Radiology. 1983; 146(2): 309-21.
[7]  Silver IM, Boag AH, Soboleski DA. Best cases from the AFIP: multilocular cystic renal tumor-cystic nephroma. Radio Graphics. 2008; 28(4): 1221-5.
[8]  González-Serrano A, Cortez-Betancourt R, Alías-Melgar A, Botello-Gómez PJ, Ramírez-Garduño E, Trujillo-Vázquez EI, et al. Multilocular Cystic Renal Cell Carcinoma or Cystic Nephroma? Case Rep Urol. 2016; 2016: 5304324.
[9]  Safaei Asl A. Benign Multilocular Cyst. Iranian J of Kidney Diseases. Iran J Kidney Dis.2009; 3(1): 54-7.
[10]  Doğan HS, Yazıcı Z, Aytaç B, Sevinir B, Erdoğan H, Çiçek C. Pediatric Multilocular Cystic Nephroma Extending into the Renal Pelvis and Ureter. J Urol Surg.2014; 1(1): 39-41.
[11]  Agarwal S, Agrawal U, Mohanty NK, Saxena S. Multilocular cystic renal cell carcinoma: a case report of a rare entity. Arch Pathol Lab Med. 2011; 135(3): 290-2.
[12]  van den Hoek J, de Krijger R, van de Ven K, Lequin M, van den Heuvel-Eibrink MM. Cystic nephroma, cystic partially differentiated nephroblastoma and cystic Wilms tumor in children: a spectrum with therapeutic dilemmas.Urol Int.2009; 82(1): 65-70.
[13]  Luithle T, Szavay P, Furtwangler R, Graf N, Fuchs J. SIOP/GPOH Study Group.Treatment of cystic nephroma and cystic partially differentiated nephroblastoma --a report from the SIOP/GPOH study group. J Urol .2007; 177(1): 294-6.