American Journal of Cancer Prevention
ISSN (Print): 2328-7314 ISSN (Online): 2328-7322 Website: http://www.sciepub.com/journal/ajcp Editor-in-chief: Nabil Abdel-Hamid
Open Access
Journal Browser
Go
American Journal of Cancer Prevention. 2016, 4(3), 41-43
DOI: 10.12691/ajcp-4-3-2
Open AccessArticle

Leiomyosarcoma after Kidney Transplantation in a Patient with Leukocytoclastic Vasculitis, Lobular Panniculitis and History of Hyperthyroidism

Mazaher Ramezani1, Fatemeh Darvishy2 and Masoud Sadeghi3,

1Molecular Pathology Research Center, Emam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Pub. Date: September 30, 2016

Cite this paper:
Mazaher Ramezani, Fatemeh Darvishy and Masoud Sadeghi. Leiomyosarcoma after Kidney Transplantation in a Patient with Leukocytoclastic Vasculitis, Lobular Panniculitis and History of Hyperthyroidism. American Journal of Cancer Prevention. 2016; 4(3):41-43. doi: 10.12691/ajcp-4-3-2

Abstract

Leiomyosarcoma is a rare, aggressive malignant connective tissue cancer of mature adults, which increases from smooth muscle and occurs most frequently in the uterus, bowel, vascular tissues, and less commonly in somatic soft tissue or bone. We reported a 35-year-old woman was referred to the gastroenterology service with abdominal pain and vomiting. She was a case of renal transplantation in right side since 5 years ago. An evaluation by ultrasound showed right chest wall soft tissue mass measuring 40x36mm with internal vascularity without rib destruction. The CT Thorax without contrast, showed a solid mass in the right lower thoracic wall measuring 42x32mm with invasion to subcutaneous fat and abdominal wall muscle. The patient had history of hyperthyroidism about two years ago, which was treated and history of cutaneous leukocytoclastic vasculitis (LCV) and lobular panniculitis since last year, which was proven by skin biopsy. Our patient sought surgical advice who asked for a biopsy which showed a malignant spindle cell tumor compatible with leiomyosarcoma extending to peripheral fatty tissue with histological grade 2. In conclusion, treatment of thyroid disorders and LCV in kidney transplanted patients can be caused malignancies. Therefore, evaluation for malignancies like sarcoma is suggested with thyroid disorders and vasculitis in the follow-up of kidney transplanted patient.

Keywords:
leiomyosarcoma leukocytoclastic vasculitis kidney transplantation

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Figures

Figure of 2

References:

[1]  Husted TL, Buell JF, Hanaway MJ, Trofe J, Beebe T, Gross T, et al. De novo sarcomas in solid organ transplant recipients. Transplant Proc. 2002; 34(5): 1786-7.
 
[2]  Cautero N, De Luca S, Vecchi A, Garelli P, Nicolini D, Martorelli G, et al. Peritoneal leiomyosarcoma in a kidney transplant patient: a case report. Transplant Proc. 2007; 39(6): 2038-9.
 
[3]  Nafar M, Einollahi B, Hemati K, Gholi FP, Firouzan A. Development of malignancy following living donor kidney transplantation. Transplant Proc. 2005; 37(7): 3065-7.
 
[4]  Deyrup AT, Lee VK, Hill CE, Cheuk W, Toh HC, Kesavan S, et al. Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients. Am J Surg Pathol. 2006; 30(1): 75-82.
 
[5]  Greer JM, Longley S, Edwards NL, Elfenbein GJ, Panush RS. Vasculitis associated with malignancy. Experience with 13 patients and literature review. Medicine (Baltimore). 1988; 67(4): 220-30.
 
[6]  Braman M, Santmyire-Rosenberger B, Dugan E, Brun E, Wang Z. Leukocytoclastic Vasculitis Presenting in Association with a Spindle Cell Sarcoma of the Heart. A Paraneoplastic Syndrome? Journal of Cutaneous Pathology. 2005; 32(1): 77.
 
[7]  Bouattar T, Kazmouhi L, Alhamany Z, Beqqal K, Haffane L, Houssaini TS, et al. Kaposi's sarcoma following immunosuppressive therapy for vasculitis. Saudi J Kidney Dis Transpl. 2011; 22(2): 319-23.
 
[8]  Basu G, Mohapatra A. Interactions between thyroid disorders and kidney disease. Indian J Endocrinol Metab. 2012 Mar; 16(2): 204-13.
 
[9]  Thalquotra M, Pandey R, Pardhe BD, Bhandari J, Singh J, Sodhi KS. Kidneys and Thyroid Gland: Interrelation in Health and Disease. Indo American Journal Of Pharm Research. 2014: 4(4): 1730-38.
 
[10]  Merimsky O, Issakov J, Kollender Y, Inbar M, Bickels J, Meller I. Sarcoma and thyroid disorders: a common etiology? Oncol Rep. 2002; 9(4): 863-9.
 
[11]  El-Khalfaoui K, du Bois A, Heitz F, Kurzeder C, Sehouli J, Harter P. Current and future options in the management and treatment of uterine sarcoma. Ther Adv Med Oncol. 2014; 6(1): 21-8.
 
[12]  Hensley ML, Wathen JK, Maki RG, Araujo DM, Sutton G, Priebat DA, et al. Adjuvant therapy for high-grade, uterus-limited leiomyosarcoma: results of a phase 2 trial (SARC 005). Cancer. 2013; 119(8): 1555-61.
 
[13]  Bhatia K, Shiels MS, Berg A, Engels EA. Sarcomas other than Kaposi sarcoma occurring in immunodeficiency: interpretations from a systematic literature review. Curr Opin Oncol. 2012; 24(5): 537-46.
 
[14]  Chelimilla H, Badipatla K, Ihimoyan A, Niazi M. A rare occurrence of primary hepatic leiomyosarcoma associated with epstein barr virus infection in an AIDS patient. Case Rep Gastrointest Med. 2013; 2013: 691862.
 
[15]  Cooper DS. Antithyroid drugs. N Engl J Med. 2005; 352(9): 905-17.
 
[16]  Miller RM, Darben TA, Nedwich J, Savige J. Propylthiouracil-induced antineutrophil cytoplasmic antibodies in a patient with Graves' disease and a neutrophilic dermatosis. Br J Dermatol. 1999; 141(5): 943-4.
 
[17]  Hutson TE, Hoffman GS. Temporal concurrence of vasculitis and cancer: a report of 12 cases. Arthritis Care Res. 2000; 13(6): 417-23.
 
[18]  Echeverría CM, Fortunato LP, Stengel FM, Laurini J, Díaz C. Pancreatic panniculitis in a kidney transplant recipient. Int J Dermatol. 2001; 40(12): 751-3.