Hepatoprotective Effects Exerted by Propolis against Doxorubicin-induced Rat Liver Toxicity: A Biochemical and Histopathological Study

Nassar Ayoub Abdellatif Omar^{1, 2}, Amal Nor Edeen Ahmad Allithy^{3, 4}, Hussam Baghdadi⁵, Mohammed Zolaly⁶, Mohamed Abdel-haleem⁷, Manal Mohamed Helmy^{8, 9}, Mongi Mohamed Ahmed Ayat^{5, 10} and Salah Mohamed El Sayed^{5, 11,}

¹Department of Anatomy, Faculty of Clinical Pharmacy, Taif University, KSA

²Department of Anatomy, Faculty of Medicine, Sohag University, Egypt

³Department of Pathology, Al-Ghad International Medical Sciences Colleges, Al-Madinah, KSA

⁴Department of Pathology, Faculty of Medicine, Sohag University, Egypt

⁵Department of Clinical Biochemistry and Molecular Medicine, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia

⁶Department of Pediatrics, College of Medicine, Taibah College of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia

⁷Department of ear, nose and throat surgery, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia

⁸Department of Pediatrics, Sohag Teaching Hospital, Sohag, Egypt

⁹Division of Pediatric cardiology, Department of Pediatrics, Maternity and Children Hospital, King Abdullah Medical City, Al-Madinah Al-Munawwarah, Kingdom of Saudi Arabia

¹⁰Department of Clinical Pathology, Faculty of Medicine, 6th October University, Cairo, Egypt

¹¹Department of Medical Biochemistry, Sohag Faculty of Medicine, Sohag University, Egypt

Cite this paper:
Nassar Ayoub Abdellatif Omar, Amal Nor Edeen Ahmad Allithy, Hussam Baghdadi, Mohammed Zolaly, Mohamed Abdel-haleem, Manal Mohamed Helmy, Mongi Mohamed Ahmed Ayat and Salah Mohamed El Sayed. Hepatoprotective Effects Exerted by Propolis against Doxorubicin-induced Rat Liver Toxicity: A Biochemical and Histopathological Study. American Journal of Cancer Prevention. 2016; 4(3):36-40. doi: 10.12691/ajcp-4-3-1

Abstract

Doxorubicin (DOX) is a currently used broad spectrum anticancer agent used to treat many cancer types. DOX belongs to anthracycline group of cytotoxic drugs. Unfortunately, DOX induces many side effects e.g. cardiotoxicity, hepatotoxicity and nephrotoxicity. In this experimental study, we assessed the protective potential of honey bee propolis against DOX-induced side effects. Thirty Sprague Dawley male rats (weighing about 200-220 g) were included in our study and divided into three equal experimental groups: group I (untreated control), group II (DOX-treated rats) that received 25 mg/kg DOX by intraperitoneal (i.p) injection for three consecutive days and group III where animals received both DOX and propolis oral propolis (250 mg/kg for 30 consecutive days). By the end of experimental time, all animals were sacrificed on the 30th day where blood samples and tissue sections were collected for detection of the biochemical and histopathological changes. Our data revealed that propolis evidently resulted in hepatoprotective effects against DOX-induced toxicity in rats liver. It can be concluded that propolis provides partial protection against DOX-induced hepatotoxicity.

Keywords:
Doxorubicin Liver toxicity anthracyclines Bee propolis Chemotherapy

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