American Journal of Cancer Prevention
ISSN (Print): 2328-7314 ISSN (Online): 2328-7322 Website: http://www.sciepub.com/journal/ajcp Editor-in-chief: Nabil Abdel-Hamid
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American Journal of Cancer Prevention. 2015, 3(5), 100-102
DOI: 10.12691/ajcp-3-5-7
Open AccessResearch Article

The Ki-67 index in non-Hodgkin's Lymphoma: Role and Prognostic Significance

Mehrdad Payandeh1, Masoud Sadeghi2, 3, and Edris Sadeghi2, 3

1Department of Hematology and Medical Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Pub. Date: October 08, 2015
(This article belongs to the Special Issue Advances in Non-Hodgkin Lymphomas)

Cite this paper:
Mehrdad Payandeh, Masoud Sadeghi and Edris Sadeghi. The Ki-67 index in non-Hodgkin's Lymphoma: Role and Prognostic Significance. American Journal of Cancer Prevention. 2015; 3(5):100-102. doi: 10.12691/ajcp-3-5-7

Abstract

Background: Ki67 is a nuclear and nuclear protein antigen present in all proliferating cells during the active part of the cell cycle: G1, S, G2, and mitosis. The aim of study is to evaluate survival based on Ki67 index in NHL patients in the west of Iran for the first time. Patients and Methods: Between of 2002 to 2014, fifty-six patients with NHL referred to Our Clinic. We checked age, sex, type of NHL, Ki67 index and survival for them. We divided Ki67 index to two groups: low Ki67 (Ki67<65%) and high Ki67 (Ki67≥65%). Results: The mean age at diagnosis for patients was 47.33±166.50 years (range, 13-77 years) that 27 patients (48.2%) had age≤ 50 years and 33 patients (58.9%) were male. Thirty-eight patients (67.9%) had Ki67<60% and 18 patients (32.1%) had Ki67≥65%. The mean Ki67 for Nodal patients was 48.1% and for extra nodal was 54.5%, but there was no significant correlation between them (P=0.360). Conclusion: Ki67 in future studies should be divided based on a fix percent until we can have a better result about the role of Ki67 in NHL patients. Also, Ki67 alone can not be a risk factor in NHL patients and other factors such as age, sex and type of NHL can be affective, too.

Keywords:
Ki67 index overall survival NHL

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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