American Journal of Cancer Prevention
ISSN (Print): 2328-7314 ISSN (Online): 2328-7322 Website: http://www.sciepub.com/journal/ajcp Editor-in-chief: Nabil Abdel-Hamid
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American Journal of Cancer Prevention. 2015, 3(5), 91-93
DOI: 10.12691/ajcp-3-5-4
Open AccessResearch Article

Epstein-Barr virus and non-Hodgkin lymphoma: A study in Kermanshah, Iran

Ali Shahriari-Ahmadi1, Babak Izadi2, Masoud Sadeghi3, 4, , Mehrdad Payandeh2 and Edris Sadeghi3, 4

1Rasool-Akram Hospital, Oncology and Hematology ward, Iran University of Medical Sciences, Tehran, Iran

2Department of Medical Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

4Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Pub. Date: October 08, 2015
(This article belongs to the Special Issue Advances in Non-Hodgkin Lymphomas)

Cite this paper:
Ali Shahriari-Ahmadi, Babak Izadi, Masoud Sadeghi, Mehrdad Payandeh and Edris Sadeghi. Epstein-Barr virus and non-Hodgkin lymphoma: A study in Kermanshah, Iran. American Journal of Cancer Prevention. 2015; 3(5):91-93. doi: 10.12691/ajcp-3-5-4

Abstract

Background: Epstein-Barr virus (EBV) infection is highly associated with specific subtypes of malignant lymphoma such as types of aggressive non-Hodgkin lymphoma (NHL). We aimed to evaluate the prevalence of EBV in NHL and its association with clinical parameters. Patients and Methods: twenty cases entered to our study. After re-blocking of previous paraffin embedded specimens, new slides were prepared and DNA was extracted. DNA contents were confirmed by spectrophotometery. Then PCR assay was used for total DNA and its product evaluate for presence of EBV by electrophoresis. Results: The mean age at diagnosis for all patients was 45±13 years (range, 28-73) years that 12 patients (60%) were male. Based on histopathology reports, 13 patients (65%) had immunoblastic Lymphoma, 5 (25%) had burkitt Lymphoma and 2 (10%) had LL (lymphoblastic Lymphoma). Conclusion: There is no EBV infection in NHL patients with LLs and percent of EBV infection in our study is lower than other studies.

Keywords:
EBV infection NHL Burkitt lymphoma

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