American Journal of Cancer Prevention
ISSN (Print): 2328-7314 ISSN (Online): 2328-7322 Website: http://www.sciepub.com/journal/ajcp Editor-in-chief: Nabil Abdel-Hamid
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American Journal of Cancer Prevention. 2015, 3(1), 4-7
DOI: 10.12691/ajcp-3-1-2
Open AccessCase Report

Different Presentation of Treatment in Carcinomatous Meningitis of Breast Cancer: Report of 3 Cases

Mehrdad Payandeh1, Edris Sadeghi2, , Masoud Sadeghi2 and Akram Mozafari Eskandar3

1Department of Hematology and Oncology, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Department of Nursing, Kermanshah University of Medical Sciences, Kermanshah, Iran

Pub. Date: February 10, 2015

Cite this paper:
Mehrdad Payandeh, Edris Sadeghi, Masoud Sadeghi and Akram Mozafari Eskandar. Different Presentation of Treatment in Carcinomatous Meningitis of Breast Cancer: Report of 3 Cases. American Journal of Cancer Prevention. 2015; 3(1):4-7. doi: 10.12691/ajcp-3-1-2

Abstract

Background: Carcinomatous Meningitis (CM) refers to the multifocal seeding of the leptomeninges by malignant cells. CM occurs in approximately 5% of patients with breast cancer. Herein, we suggest that Intrathecal (IT) can use in treatment of breast cancer patients with CM before of any treatment until can prevent of going patient to debilitating phase of this disease. Patients and Methods: Three patients with high risk breast cancer with CM: A 62 year-old Kurdish woman with a history of lung tuberculosis. Her cerebrospinal fluid was positive for malignant cells. She treated with IT chemotherapy and died 3 months after diagnosis of CM. A 48 year-old woman in premenopausal states had a left axillary mass for last 4 months. After one year of followed up she complaints with refractory headache. In cerebrospinal fluid (CSF) analysis with diagnosis of CM treated with brain irradiation and multiple courses of IT chemotherapy. After six months she is well still and in follow up with previous drug list and monthly IT chemotherapy. A 63 year-old woman was presented at the emergency department of our hospital. After 4 months of her treatment she complained from decrease of consciousness and in CSF analysis with positive cytology. She treated with IT chemotherapy and She died about 2 weeks ago with exacerbation of brain tumor. Conclusion: According to the poor prognosis of this disease it is better that in high risk breast cancer patients like Non-Hodgkin lymphoma (NHL) high risk patients. IT prophylaxis was done for these high risk patients because by this way, we can prevent of going patient to debilitating phase of this disease.

Keywords:
Breast Cancer CM IT Chemotherapy NHL

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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