American Journal of Cancer Prevention
ISSN (Print): 2328-7314 ISSN (Online): 2328-7322 Website: http://www.sciepub.com/journal/ajcp Editor-in-chief: Nabil Abdel-Hamid
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American Journal of Cancer Prevention. 2020, 8(1), 7-12
DOI: 10.12691/ajcp-8-1-2
Open AccessArticle

Histone Acetylation Modification H4K16ac Involved in Notch1 Signaling in Breast Cancer

Ya-qi Wang1, , Jing-hua Zhang2, , Zhao-yuan Wan3 and Dan Li3

1Department of Surgical Oncology, Tangshan People's Hospital, Tangshan, China

2Department of Surgical, Tangshan Women and Children's Hospital, Tangshan, China

3Cancer Institute, Tangshan People’s Hospital, Tangshan, China

Pub. Date: December 11, 2020

Cite this paper:
Ya-qi Wang, Jing-hua Zhang, Zhao-yuan Wan and Dan Li. Histone Acetylation Modification H4K16ac Involved in Notch1 Signaling in Breast Cancer. American Journal of Cancer Prevention. 2020; 8(1):7-12. doi: 10.12691/ajcp-8-1-2

Abstract

The Notch signaling pathway is a fundamental intercellular signaling system that regulates cell fate decisions in terms of proliferation and differentiation in multiple tissues. Abnormal activation of Notch1 signaling pathway leads to a variety of diseases, including the malignant tumors. Dysregulated Notch receptor activity has been implicated in breast cancer but the epigenetic mechanisms remains not clear. Compared to adjacent tissues, high expression of NIC1 and low expression of H4K16ac were found in cancer tissues. Notch1 knocked down in the breast cancer cell line MCF-7 resulted in increased H4K16ac expression and a parallel reduction in their proliferation and migration capacity. Our study prompting H4K16ac to participate in the signal transduction of Notch1 in breast cancer cells. These results confirm Notch1 as a signal triggering epigenetic mechanisms in breast cancer cells, which may have implications in tumor dissemination, metastasis and proliferation. The identification of specific factors interacting with NOTCH signaling could thus be relevant to fully understanding the role of NOTCH in breast neoplasia.

Keywords:
breast cancer notch1 signaling in tumorigenesis epigenetic modification H4K16ac

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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