American Journal of Clinical Medicine Research
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American Journal of Clinical Medicine Research. 2018, 6(2), 24-34
DOI: 10.12691/ajcmr-6-2-2
Open AccessReview Article

A Review of Signaling Pathways and the Genetics Involved in the Development of Type 2 Diabetes: Investigating the Possibility of a Vaccine and Therapeutic Interventions to Prevent Diabetes

Sabitha Vadakedath1, Venkataramana Kandi2, , Venkata Bharat Kumar Pinnelli3 and Vikram Godishala4

1Department of Clinical Biochemistry, Chalmeda Anandrao Institute of Medical Sciences, Karimnagar, Telangana, India

2Department of Clinical Microbiology, Prathima Institute of Medical Sciences, Karimnagar, Telangana, India

3Department of Biochemistry, Vydehi Institute of Medical Sciences and Research Centre, #82, EPIP Area, Nallurhalli, Whitefield, Bangalore – 560066, Karnataka, India

4Department of Biotechnology, Vaagdevi Degree and PG College, Warangal, Telangana, India

Pub. Date: May 30, 2018

Cite this paper:
Sabitha Vadakedath, Venkataramana Kandi, Venkata Bharat Kumar Pinnelli and Vikram Godishala. A Review of Signaling Pathways and the Genetics Involved in the Development of Type 2 Diabetes: Investigating the Possibility of a Vaccine and Therapeutic Interventions to Prevent Diabetes. American Journal of Clinical Medicine Research. 2018; 6(2):24-34. doi: 10.12691/ajcmr-6-2-2


Diabetes mellitus is a chronic debilitating non-communicable disease prevalent throughout the world. There are two different types of diabetes; the type 1 diabetes usually presents in children and young adults, and the type 2 diabetes, a most frequent age-related condition usually noted among the adults aged over 40 years. The type 1 diabetes results due to an immunological reaction against insulin and the insulin secreting cells. The type 2 diabetes can occur due to various factors that include genetic predisposition, lifestyle disorders, insulin resistance, and lack of adequate insulin production. Since lifestyle management is an adjustable risk factor for diabetes, may people with genetic predisposition could delay the onset of clinical diabetes. Further there is an increasing need to understand the genetics behind the signaling pathways involved in the development of type 2 diabetes, which could pave the way for formulating, and implementing therapeutic, and preventive strategies.

diabetes mellitus non-communicable disease type 1 diabetes type 2 diabetes genetic predisposition insulin resistance signaling pathways

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