American Journal of Clinical Medicine Research
ISSN (Print): 2328-4005 ISSN (Online): 2328-403X Website: Editor-in-chief: Dario Galante
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American Journal of Clinical Medicine Research. 2017, 5(4), 59-63
DOI: 10.12691/ajcmr-5-4-5
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Rising Mean Platelet Volume (MPV) Heralding Platelets Recovery in Dengue?

Ajay Khandal1, and D. Raghuraman2

1Department of Medicine, Prathima Institute of Medical Sciences, Karimnagar, India

2Chairman Institutional ethics committee, Prathima Institute of Medical Sciences, Karimnagar, India

Pub. Date: July 20, 2017

Cite this paper:
Ajay Khandal and D. Raghuraman. Rising Mean Platelet Volume (MPV) Heralding Platelets Recovery in Dengue?. American Journal of Clinical Medicine Research. 2017; 5(4):59-63. doi: 10.12691/ajcmr-5-4-5


Infectious diseases including Dengue illness remains the commonest cause of hospitalization in Indian settings. It is a significant global public health problem, with 2.5 billion world's population at risk and an estimated 50 to 390 million annual infections. Clinically, dengue illness manifestation varies from asymptomatic state to severe symptomatic disease. Symptomatic disease events in turn range from self-limiting dengue fever (DF) to severe dengue. Severe dengue, manifests as; dengue hemorrhagic fever (DHF), hypovolemic shock—dengue shock syndrome (DSS) or severe organ impairment. Thrombocytopenia is a common element to both dengue fever and severe dengue; and clinicians, unfortunately, tend to ‘react' to thrombocytopenia with platelet transfusions at predetermined platelet thresholds. Readily available lab parameters to guide the clinician of impending platelet recovery is needed, one such parameter gaining recent interest is Platelet Indices (PIs): mean platelet volume (MPV) and platelet distribution width (PDW). Serially observing mean platelet volume along with Platelets might be valuable, with a rising trend in MPV suggesting platelet and patient recovery.

dengue thrombocytopenia dengue cost of hospitalization thrombocytopenia mechanisms

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