American Journal of Clinical Medicine Research
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American Journal of Clinical Medicine Research. 2014, 2(6), 111-113
DOI: 10.12691/ajcmr-2-6-2
Open AccessReview Article

Pre Eclampsia: Its Effect on Renal, Cardiovascular, Hepatic and Thyroid Functions a Review

Sabitha kandi1, B Venu Gopal1, Raj Kumar G1, MD Rafi1, T Sudhakar1, C Ramadevi2, Mamatha2, Pragna Rao3 and K V Ramana4,

1Department of Biochemistry, Chalmeda Anandrao Institute of Medical Sciences, Karimnagar, India

2Department of Obstetrics and Gynaecology, Chalmeda Anandrao Institute of Medical Sciences, Karimnagar, India

3Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal, India

4Department of Microbiology, Prathima Institute of Medical Sciences, Karimnagar, India

Pub. Date: December 22, 2014

Cite this paper:
Sabitha kandi, B Venu Gopal, Raj Kumar G, MD Rafi, T Sudhakar, C Ramadevi, Mamatha, Pragna Rao and K V Ramana. Pre Eclampsia: Its Effect on Renal, Cardiovascular, Hepatic and Thyroid Functions a Review. American Journal of Clinical Medicine Research. 2014; 2(6):111-113. doi: 10.12691/ajcmr-2-6-2

Abstract

Preeclampsia is a severe disorder of pregnancy characterized by the development of hypertension and proteinuria, increased vascular resistance and endothelial dysfunction in the mother, altered placental perfusion and restricted fetal growth. There is increased release of soluble growth factor like sFlt 1 from placenta, which decreases the availability of Vascular Endothelial Growth Factor(VEGF) receptors and decreases the availability of endothelial Nitric Oxide synthase. This inturn decreases the diastolic relaxation and endothelial dysfunction, podocyte injury of glomerular cells, increased excretion of podocyte specific proteins in urine leads to proteinuria. Cardiac hypertrophy further complicates the heart function. There is a raise in liver function; soluble factor like tyrosine kinase 1 (sFlt 1) may cause a disturbance in thyroid hormone function, thus prone to thyroid problem during or after pregnancy.

Keywords:
preeclampsia proteinuria cardiac hypertrophy soluble factor like tyrosine kinase 1 (sFlt 1) endothelial dysfunction

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