American Journal of Clinical Medicine Research
ISSN (Print): 2328-4005 ISSN (Online): 2328-403X Website: http://www.sciepub.com/journal/ajcmr Editor-in-chief: Dario Galante
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American Journal of Clinical Medicine Research. 2021, 9(1), 10-13
DOI: 10.12691/ajcmr-9-1-3
Open AccessArticle

Hericium Erinaceus Polysaccharide Induced Maturation of Murine Bone Marrow Deprived Dendritic Cells

Lujiang Yi1, Ye Jiang1 and Lu Yang2,

1#These authors contributed equally to this work.

2Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, P. R. China

Pub. Date: December 29, 2020

Cite this paper:
Lujiang Yi, Ye Jiang and Lu Yang. Hericium Erinaceus Polysaccharide Induced Maturation of Murine Bone Marrow Deprived Dendritic Cells. American Journal of Clinical Medicine Research. 2021; 9(1):10-13. doi: 10.12691/ajcmr-9-1-3

Abstract

Hericium erinaceus polysaccharide (HEP) is a Chinese herb and was reported to regulate the immune response effectively in different aspects. This study was aimed to investigate the influence of HEP on murine dendritic cells (DC). In this study, we found that HEP treatment induced DC maturation by the morphology and the up-regulation of co-stimulative molecules. The endocytosis activity was also reduced, which is also an important feature of maturation. HEP also increased the allogenic T cell proliferation in a MLR assay. Furthermore, it was found that HEP increase the expression level of IL-12. Finally, we concluded that HEP induced maturation of bone marrow DC.

Keywords:
Hericium erinaceus polysaccharide Chinese herb immunity Dendritic cells

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