American Journal of Clinical Medicine Research
ISSN (Print): 2328-4005 ISSN (Online): 2328-403X Website: Editor-in-chief: Dario Galante
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American Journal of Clinical Medicine Research. 2021, 9(1), 10-13
DOI: 10.12691/ajcmr-9-1-3
Open AccessArticle

Hericium Erinaceus Polysaccharide Induced Maturation of Murine Bone Marrow Deprived Dendritic Cells

Lujiang Yi1, Ye Jiang1 and Lu Yang2,

1#These authors contributed equally to this work.

2Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, P. R. China

Pub. Date: December 29, 2020

Cite this paper:
Lujiang Yi, Ye Jiang and Lu Yang. Hericium Erinaceus Polysaccharide Induced Maturation of Murine Bone Marrow Deprived Dendritic Cells. American Journal of Clinical Medicine Research. 2021; 9(1):10-13. doi: 10.12691/ajcmr-9-1-3


Hericium erinaceus polysaccharide (HEP) is a Chinese herb and was reported to regulate the immune response effectively in different aspects. This study was aimed to investigate the influence of HEP on murine dendritic cells (DC). In this study, we found that HEP treatment induced DC maturation by the morphology and the up-regulation of co-stimulative molecules. The endocytosis activity was also reduced, which is also an important feature of maturation. HEP also increased the allogenic T cell proliferation in a MLR assay. Furthermore, it was found that HEP increase the expression level of IL-12. Finally, we concluded that HEP induced maturation of bone marrow DC.

Hericium erinaceus polysaccharide Chinese herb immunity Dendritic cells

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[1]  Banchereau, J. and R.M. Steinman, Dendritic cells and the control of immunity. Nature, 1998. 392(6673): p. 245-52.
[2]  Xu, H.M., Z.H. Xie, and W.Y. Zhang, [Immunomodulatory function of polysaccharide of Hericium erinaceus]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 1994. 14(7): p. 427-8.
[3]  Han, Z.H., J.M. Ye, and G.F. Wang, Evaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharides. Int J Biol Macromol. 52: p. 66-71.
[4]  Lee, J.S., et al., Study of macrophage activation and structural characteristics of purified polysaccharides from the fruiting body of Hericium erinaceus. J Microbiol Biotechnol, 2009. 19(9): p. 951-9.
[5]  Uto, T., et al., Targeting of antigen to dendritic cells with poly(gamma-glutamic acid) nanoparticles induces antigen-specific humoral and cellular immunity. J Immunol, 2007. 178(5): p. 2979-86.
[6]  Uto, T., et al., Inhibitory effect of cepharanthine on dendritic cell activation and function. Int Immunopharmacol. 11(11): p. 1932-8.
[7]  Qiu, T., et al., Lentiviral-mediated shRNA against RelB induces the generation of tolerogenic dendritic cells. Int Immunopharmacol. 12(3): p. 501-9.
[8]  Li, X., et al., Maturation of murine bone marrow-derived dendritic cells induced by Radix Glycyrrhizae polysaccharide. Molecules. 17(6): p. 6557-68.
[9]  de Jong, E.C., H.H. Smits, and M.L. Kapsenberg, Dendritic cell-mediated T cell polarization. Springer Semin Immunopathol, 2005. 26(3): p. 289-307.
[10]  Kim, Y.O., et al., Hericium erinaceus suppresses LPS-induced pro-inflammation gene activation in RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 34(3): p. 504-12.
[11]  Wang, J.C., et al., Antitumor and immunoenhancing activities of polysaccharide from culture broth of Hericium spp. Kaohsiung J Med Sci, 2001. 17(9): p. 461-7.
[12]  Viney, J.L., et al., Expanding dendritic cells in vivo enhances the induction of oral tolerance. J Immunol, 1998. 160(12): p. 5815-25.
[13]  Al-Safi, S.A. and J.L. Maddocks, Azathioprine and 6-mercaptopurine (6-MP) suppress the human mixed lymphocyte reaction (MLR) by different mechanisms. Br J Clin Pharmacol, 1984. 17(4): p. 417-22.
[14]  Szawlowski, P.W. and J.L. Maddocks, Effect of interleukin-2 on the inhibition of the human mixed lymphocyte reaction (MLR) by azathioprine. Br J Clin Pharmacol, 1985. 20(2): p. 107-10.
[15]  Al-Safi, S.A. and J.L. Maddocks, Effects of azathioprine on the human mixed lymphocyte reaction (MLR). Br J Clin Pharmacol, 1983. 15(2): p. 203-9.