American Journal of Biomedical Research
ISSN (Print): 2328-3947 ISSN (Online): 2328-3955 Website: http://www.sciepub.com/journal/ajbr Editor-in-chief: Hari K. Koul
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American Journal of Biomedical Research. 2013, 1(4), 86-92
DOI: 10.12691/ajbr-1-4-4
Open AccessArticle

Anticoagulant and Antioxidant Activities of Dracaena arborea Leaves (Wild.) Link

Nwaehujor Chinaka O.1, , Ode Julius O.2, Nwinyi Florence C.2 and Madubuike Stella A.3

1Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Nigeria

2Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Abuja, Nigeria

3Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria

Pub. Date: October 20, 2013

Cite this paper:
Nwaehujor Chinaka O., Ode Julius O., Nwinyi Florence C. and Madubuike Stella A.. Anticoagulant and Antioxidant Activities of Dracaena arborea Leaves (Wild.) Link. American Journal of Biomedical Research. 2013; 1(4):86-92. doi: 10.12691/ajbr-1-4-4

Abstract

The crude methanol extract of Dracaena arborea leaves induced significant (p<0.01) increase in the clotting times of 21 ± 0.54 sec and 25 ± 1.1 sec at 5% and 10% concentrations of the extract respectively compared to the baseline clotting time of 7 ± 0.63 sec for the blood sample. The extract also exhibited potent in vivo and in vitro anticoagulant activities. Increased doses (100 and 200 mg/kg) of the extract, heparin (0.75 and 1.5 mg/kg) and aspirin (1.0 and 2.0 mg/kg) were found to have significantly (p < 0.01) prolonged the mean bleeding times with respect to the baseline in rabbits. However, in thrombin-induced clotting assay, the extract demonstrated a reduced potency compared to heparin. DPPH (1, 1-Diphenyl-2-picrylhydrazyl) and FRAP (Ferric reducing/antioxidant power) spetrophotometric assays revealed that the crude leaf extract possesses appreciable high antioxidant potentials. Dracaena arborea leaves (Wild.) Link could be a source of novel anticoagulant and antioxidant compounds for the management of various hematological disorders.

Keywords:
anticoagulant Dracaena arborea antioxidant clotting time stroke thrombin

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