American Journal of Biomedical Research
ISSN (Print): 2328-3947 ISSN (Online): 2328-3955 Website: Editor-in-chief: Hari K. Koul
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American Journal of Biomedical Research. 2017, 5(2), 35-38
DOI: 10.12691/ajbr-5-2-3
Open AccessArticle

Abzymes in the Diagnosis of Bronchial Asthma

Cyrille Alode VODOUNON1,

1Laboratoire de Biochimie et de Microbiologie, Ecole Normale Supérieure de Natitingou, University of Parakou

Pub. Date: April 17, 2017

Cite this paper:
Cyrille Alode VODOUNON. Abzymes in the Diagnosis of Bronchial Asthma. American Journal of Biomedical Research. 2017; 5(2):35-38. doi: 10.12691/ajbr-5-2-3


The objective of the present work was to study the predominance of abzymes in the diagnosis of Bronchial Asthma. The study was carried out using the blood serum of several groups of patients, including patients with Bronchial Asthma (n=15), allergic Rhino-conjunctivitis (polypus)(n=15), Systemic Lupus Erythématosis(n=10) and Auto-Immune Thyroiditis (n=10). Detection of IgG auto-AB against DNA was carried out by Enzyme-linked immunosorbent assay (ELISA) and the catalytic activity of antibody against DNA was determined by electrophoresis method. The results of our study revealed abundant auto-antibodies to DNA in the blood vessels of the patients with bronchial asthma and there was a direct correlation dependence (r=0.0005) between the level of auto-antibodies to DNA and the severity of the disease. Circulating auto-antibodies in blood serum possess catalytic activity of DNA which is associated with the degree of severity of asthma. Thus, autoantibody can be used as serologic markers for the diagnosis of BA and can even be suitable, according to their concentration, for determining the degree of severity of the disease.

Abzyme autoantibody Bronchial Asthma

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[1]  Rottem M, Shoenfeld Y. Asthma as a paradigm for autoimmune disease. Int. Arch. Allergy. Immunol 2003, 3: 210-214.
[2]  R Brouwer, G J D Hengstman, W Vree Egberts, H Ehrfeld, B Bozic, A Ghirardello, G Grøndal, M Hietarinta, D Isenberg, Autoantibody profiles in the sera of European patients with myositis. Ann Rheum Dis 2001; 60: 116-123.
[3]  Beland K, Lapierre P, Marceau G, Alvarez F: Anti-LC1 autoantibodies in patients with chronic hepatitis C virus infection. J Autoimmun 2004, 22:159-166.
[4]  Vitozzi S, Lapierre P, Djilali-Saiah I, Marceau G, Beland K, Alvarez F: Anti-soluble liver antigen (SLA) antibodies in chronic HCV infection. Autoimmunity 2004, 37:217-222.
[5]  Eirini I Rigopoulou, Maria Mytilinaiou, Ourania Romanidou, Christos Liaskos and George N Dalekos Autoimmune hepatitis-specific antibodies against soluble liver antigen and liver cytosol type 1 in patients with chronic viral hepatitis. Journal of Autoimmune Diseases 2007, 4:2.
[6]  National Heart, Blood, and lung Institute, Global strategy for asthma management and prevention: WHO|NHLBI workshop report, M.D.Bethesda, National Heart, Lung, and Blood Institute; publication1 1995, 95-3659.
[7]  National Asthma Education and Prevention Pro-gram, Expert panel report 2: guidelines for the management of asthma, M.D.Bethesda, National Institutes of Health, Publication 1.1997, 97-4051.
[8]  Goldsby R.A, Kindt T.J, Osborn B.A. Enzyme-linked Immunosorbent Assay Immunology 2003, 5: 148-150.
[9]  Tedeschi A, Asero R. Asthma and autoimmunity: a complex but intriguing relation. Expert Rev Clin Immunol 2008; 4(6): 767-776.
[10]  Lidor, Y, Topilsky M, Spitzer S.A. Yeehoshua H. Autoimmune antibodies in intrinsic (non-atopic) asthma. Ann. Allergy 1980; 5: 296-298.
[11]  Sébastien Lacroix-Desmazes, Jagadeesh Bayry, Michel D. Kazatchkine et Srini V. Kaveri. Anticorps catalytiques ou abzymes; Catalytic activity of antibodies. médecine sciences 2003; 5: 519-522.
[12]  Sébastien Lacroix-Desmazes, Alexandre Moreau, Jagadeesh Bayry, Michel D. Kazatchkine, Srinivas V. Kaveri Activité hydrolytique des anticorps anti-F VIII inhibiteurs chez les patients hémophiles A. Hematologie 2002; 6: 422-426.
[13]  Tirosh, A, Mandel D, Mimouni F.D et al. Autoimmune diseases in asthma. Ann. Intern. Med 2006; 12: 877-883.