An Overview on Biological Weapons and Bioterrorism

Mahendra Pal¹, Meron Tsegaye², Fikru Girzaw², Hailegebrael Bedada², Vikram Godishala³ and Venkataramana Kandi^4,

¹Consultant of Veterinary Public Health and Microbiology, 4 Aangan, Jagnath Ganesh Dairy Road, Anand-388001, India

²College of Veterinary Medicine, Samara University, P.O.Box.No.132, Samara, Ethiopia

³Department of Biotechnology, Vaagdei Degree and PG College, Warangal, India

⁴Department of Microbiology, Prathima Institute of Medical Sciences, Nagunur, Karimnagar, India

Cite this paper:
Mahendra Pal, Meron Tsegaye, Fikru Girzaw, Hailegebrael Bedada, Vikram Godishala and Venkataramana Kandi. An Overview on Biological Weapons and Bioterrorism. American Journal of Biomedical Research. 2017; 5(2):24-34. doi: 10.12691/ajbr-5-2-2

Abstract

Bioterrorism is the deliberate or threatened use of biological agents; viruses, bacteria, toxins or other agents to cause illness or death in people, animals, or plants. Since most priority bioterrorism agents are zoonotic in origin, there is a heightened awareness and concern about the possibility of bioterrorism involving animals. Veterinarians and livestock owners may be the first to diagnose the early cases of a bioterrorist act, as livestock can be sentinels of such an exposure. List of the most likely biological agents to be used in an act of bioterrorism had been prioritized and these agents are classified into A, B and C categories. Category A agents and disease are easily transmitted from animals to human, (except for smallpox, which has no animal reservoir) person to person, having high mortality rates and potential for a major public health impact. Category B agents and disease are moderately easy to disseminate and result in moderate morbidity rates and low mortality rates. Category C agents and diseases include emerging pathogens that could be engineered for mass dissemination. Although society has limited ability to prevent bioterrorist attacks, there still is a need to take preventative steps to reduce potential risks for such attacks. Increased laboratory scrutiny for disease agents, greater controls for investigations involving these pathogens and other security measures implemented, are necessary to restrict access to dangerous biological agents. Detection of disease in animals may be essential in predicting a bioterrorism event since most threat agents of bioterrorism are microbes causing zoonotic diseases. Veterinarians and veterinary diagnostic laboratories should become a part of nationwide active surveillance for category A, B, and C agents and diseases, as well as for new and emerging bioterrorism agents.

Keywords:
bioterrorism biological weapons biowarfare zoonoses public health

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References:

[1]	Alibek, K. and Handelman, S. (1999). Biohazard: The Chilling True Story of the Largest Covert Biological Weapons Program in the World - Told From Inside by the Man Who Ran It. New York, NY: Random House; 1999.
[2]	Arnon, S.S., Schechter, R., Inglesby, T.V., Henderson, D.A., Bartlett, J.G., Ascher, M.S., Eitzen, E., Fine, A.D., Hauer, J., Layton, M., Lillibridge, S., Osterholm, M.T., O'Toole, T., Parker, G., Perl, T.M., Russell, P.K., Swerdlow, D.L. and Tonat, K. (2001). Botulinum toxin as a biologicalweapon: medical and public health management. JAMA, 285:1059-1070.
[3]	Association for Professionals in Infection Control and Epidemiology. (1999). Bioterrorism Readiness Plan: A Template for Healthcare Facilities. USA: APIC.
[4]	Baca, O.G. and Paretsky, D. (1983). Q fever and C.burnetii: a model for host-parasite interactions. Microbiol. Rev., 47: 127-149.
[5]	Benenson, A. (1995). Control of Communicable Diseases Manual, 16th ed. American Public Health Association, Baltimore: United Book Press.
[6]	Bhalla, D.K. and Warheit, D.B. (2004). Biological agents with potential for misuse: a historical perspective and defensive measures. Toxicol.Appl.Pharmacol. 199: 71-84.
[7]	Biological and chemical terrorism: strategic plan for preparedness and response (2000). recommendations of theCDC Strategic Planning Workgroup. MMWR Morb.Mortal.Wkly.Rep., 49: 1-14.
[8]	Carlisle, P.A. (2005). Strategic Studies Institute, US Army War College, 2005. Available at: http://www.strategicstudiesinstitute.army.mil/Pubs/display.
[9]	Cenciarelli, O, Rea S, Carestia M, D'Amico F, Malizia A, Bellecci C, Gaudio P, Gucciardino A, Fiorito R. Defence S&T Technical Bulletin. 2013, Vol. 6 Issue 2, p111-129.
[10]	CDC (1999). Bioterrorism Alleging Use of Anthrax and Interim Guidelines for Management-United States. Morb. Mortal. Wkly Rep., 48: 69-74.
[11]	CDC (2000). Biological and chemical terrorism: strategic plan for preparedness and response: recommendations of the CDC Strategic Planning Workgroup. MMWR Morb. Mortal. Wkly. Rep., 49: 1-14.
[12]	CDC (2000). Laboratory-acquired human glanders Marlyland. MMWR, 49: 532-535.
[13]	CDC (2001). Center for Law and the Public's Health at Georgetown and Johns Hopkins Universities. The Model State Emerg. Health Powers Act., 12: 25-28.
[14]	CDC (2001). Recognition of illness associated with the intentional release of a biologic agent. MMWR Morb. Mortal. Wkly. Rep., 50: 893-897.
[15]	CDC (2013). Bioterrorism agents /diseases, CDC website. Available at: http://emergency.cdc.gov /agent/agentlist-category.asp.
[16]	Centers for Disease Control and Prevention, 2003, Multistate outbreak of monkeypox—Illinois, Indiana, and Wisconsin, 2003: Morb. Mortal.Wkly Rep., 52: 537-540.
[17]	Christopher, G.W., Cieslak, T.J., Pavlin, J.A. and Eitzen, E.M. (1997). Biological warfare: a historical perspective. JAMA, 278: 412-417.
[18]	Clark, D.V., Jahrling, P.B. & Lawler, J.V. (2012). Clinical management of filovirus infected patients. Viruses, 4:1668-1686.
[19]	Cottrell, T.S. and Morgan. E.R. (2003). Animal surveillance in NBC defensive operations. .J. R. Army Med. Corps, 149: 225-30.
[20]	Danzig, R. and Berekowsky, P. (1997). Why should we be concerned about biological warfare? J. Amer. Med. Asso., 12: 431-432.
[21]	Daszak, P., Cunningham, A. A. and Hyatt, A. D. (2000). Emerging infectious diseases of wildlife-threats to biodiversity and human health. Sci., 287: 443-449.
[22]	Davis, C.J. (1999). Nuclear blindness: an overview of the biological weapons programs of the former Soviet Union and Iraq: Emerg.Infect.Dis.,5:509-512.
[23]	Davis, R,G. (2004). The ABCs of bioterrorism for veterinarians, focusing on Category A agents. J. Am. Vet. Med. Assoc., 224: 1084-1095.
[24]	Dennis, D.T., Inglesby, T.V. and Henderson, D.A. (2001). Tularemia as a biological weapon: medical and public health management. JAMA.285:2763-2773.
[25]	Dobson, A.P. (1994). The ecology and epidemiology of rinderpest virus in Serengeti and Ngorogoro Conservation Area: Research, Management, and Conservation of an Ecosystem. Chicago: University of Chicago Press. Google Scholar Pp 485-505.
[26]	DSHS (2011). History of bioterrorism. Available at: http://www.dshs.state .tx.us/preparedness/.
[27]	Eitzen, E.M. (1997). Use of biological weapons. In Zajtchuk, R. & Bellamy, R.F. (Eds.), Textbook of Military Medicine: Medical Aspects of Chemical and Biological Warfare. Office of the Surgeon General. U.S. Department of the Army, Washington. D.C., pp. 437-450.
[28]	First, W.H., 2002: When every moment counts: what you need to know about bioterrorism from the Senate’s only doctor: Lanham, Md., Rowman and Littlefield Publishers, Inc., 181 p.
[29]	Harris, S.H., 2002: Factories of death: Japanese biological warfare, 1932–1945, and the American cover-up: New York, N.Y., Routledge, 385 p.
[30]	Heath, D.G., Anderson, G.W. and Mauro, J.M. (1998). Protection against Experimental Bubonic and Pneumonic Plague by a Recombinant Capsular F1-V Antigen Fusion Protein Vaccine, JAMA, 16: 1131-1137.
[31]	Henderson, D.A. (1999). The looming threat of bioterrorism: Sci., 283: 1279-1282.
[32]	Holtzman, J. (2001). The food of elders, the “ration” of women: Brewing, gender, and domestic processes among the Samburu of northern Kenya. Amer. Anthropol. Sci. Google Scholar. 103: 1041-1058.
[33]	Inglesby, T.V, Dennis, D.T. and Henderson, D.A. (2000). Plague as a biological weapon: medical and public health management. Working Group on Civilian Biodefense.JAMA.283:2281-2290.
[34]	Inglesby, T.V., O’Toole, T. and Henderson D.A. (2002). Anthrax as a biological weapon: updated recommendations for management. JAMA. 287: 2236-2252.
[35]	Joseph P. Dudley, Michael H. Woodford; Bioweapons, Biodiversity, and Ecocide: Potential Effects of Biological Weapons on Biological Diversity: Bioweapon disease outbreaks could cause the extinction of endangered wildlife species, the erosion of genetic diversity in domesticated plants and animals, the destruction of traditional human livelihoods, and the extirpation of indigenous cultures. BioScience 2002; 52 (7). 583-592.
[36]	Kortepeter, M.G. & Parker, G.W. (1999). Potential biological weapons threats. Emerg. Infect. Dis., 5:523-527.
[37]	La Placa, M. (2010). Principles of Medical Microbiology. Esculapio, Lahore.
[38]	Legvold, R. (2012). The Soviet Biological Weapons Program: A History. Fore. Aff., 91: 184-185.
[39]	Leitenberg, M. (2001). Biological Weapons in the Twentieth Century: A Review and Analysis. Crit. Rev. Microbiol., 27: 267.
[40]	Manchee, R.J., Broster, M.G., Melling, J., Henstridge, R.M. & Stagg A.J. (1981). Bacillus anthracis on Gruinard Island. Natur., 294: 254-255.
[41]	Mayor, M. and Andrienne, R. (2003). Greek Fire, Poison Arrows, and Scorpion Bombs: Biological and Chemical Warfare in the Ancient World. The Overlook Press, Peter Mayer Publishers, Pp 100-101.
[42]	Misra, C., Mukesh, S. and Thakur, V. (1995). Glanders: an appraisal and its control in India. Ind. Vet. Med. J., 19: 87-98.
[43]	National Institute of Occupational Safety and Health. Registry of Toxic Effects of Chemical Substances(R-TECS). Cincinnati, Ohio: National Institute of Occupational Safety and Health; 1996.
[44]	Newark, T. (1988). Medieval Warfare. Bloomsbury Bools, London.
[45]	Noah, D.L, Naoh, D.L. and Crowder, H.R. (2003). Biological terrorism against animals and humans: a brief review and primer for action. J. Am Vet. Med. Asso., 221: 40-43.
[46]	North Atlantic Treaty Organization (NATO) (1996). .NATO Handbook on theMedical Aspects of NBC Defensive Operations AMedP-6(B).Part II -Biological. U.S. Department of the Army, Washington DC.
[47]	Pal, M. (2007). Zoonoses.2nd Ed. Satyam Publishers, Jaipur, India.
[48]	Pal, M. (2013). Public health concern due to emerging and re-emerging zoonoses. International J. Livestock health 3: 56-62.
[49]	Perry, R.D. and Fetherson, J.D. (1997). Yersinia pestis Etiologic Agent of Plague. Clin.Microbiol. Rev., 10: 35-66.
[50]	Pinson, L., Johns, M. and Ackerman, G. (2013). Ricin Letters Mailed to President and Senator. National Consortium for the Study of Terrorism and Responses to Terrorism
[51]	Polhuijs, M., Langenberg, J. and Benschop, H. (1997). New method for retrospective detection of exposure of biological weapons: application to alleged Sarin victims of Japanese terrorists. Toxic.Appl.Pharma., 146: 156-161.
[52]	Poupard, J.A. & Miller, L.A. (1992). History of biological warfare: Catapults to capsomers. Ann. N. Y. Acad. Sci., 666: 9-20.
[53]	Rebmann, T., Wilson, R. and LaPointe, S. (2009). Hospital infectious disease emergency preparedness: A survey of infection control professionals. Am. J. Infect. Control, 37: 1-8.
[54]	Roberts, B. (1993). New Challenges and new policy properties for the 1990s. In Biological Weapons: Weapons of the Future. Washington: Centre for Strategic and International Studies.
[55]	Roxas-Duncan, V.I., Smith, L.A. and Ricin, B. (2012). Perspective in bioterrorism.
[56]	Sinclair A. R. E. (1979). Dynamics of the Serengeti ecosystem. Norton-Griffiths M, ed. Serengeti: Dynamics of an Ecosystem. Chicago: University of Chicago. Google Scholar, Pp 1-30.
[57]	Sokolski, H.D. & James M. Ludes. (2001). Twenty-First Century Weapons Proliferation. Routledge, London
[58]	Steffen, R. (1997). Preparation for emergency relief after biological warfare. J. Infect., 342: 127-132.
[59]	Stochkholm International Peace Research Institute (SIPRI) (1973). The Problem of Chemical and Biological Warfare, Vol. 3: CBW and the Law of War. Humanity Press. New York.
[60]	United States General Accounting Office (2003). Report to Congressional Committees. Bioterrorism: preparedness varied across state and local jurisdictions. Report GAO-03-373. Washington, DC:US General Accounting Office.
[61]	Wheelis, M. (2002). Biological warfare at the 1346 siege of Caffa. Emerg. Infect. Dis., 8: 23-30.
[62]	Wheelis, M. (2002). Biotechnology and biochemical weapons. Nonproliferation Rev., 9: 48-53.
[63]	Zalini, Y. (2010). Combating and reducing the risk of biological threats. J. Defence Secur., 1: 1-15.
[64]	Zilinskas, R. (1997). Iraq’s biological weapons: the past as future. JAMA, 278: 418-424.
[65]	Zilinskas, R. (2003). Terrorism and biological weapons: Inevitable alliance, Persp. Biol. Med., 34: 44-72.