The Effect of Giving Trigona Honey and Honey Propolis Trigona to the mRNA Foxp3 Expression in Mice Balb/c Strain Induced by Salmonella Typhi

Andi Nilawati Usman¹, Yuliana Syam², Rosdiana Natzir³, Sutji Pratiwi Rahardjo⁴, Mochammad Hatta^5, , Ressy Dwiyanti⁶, Yuyun Widaningsih⁷, Ainurafiq⁸ and Prihantono⁹

¹Department of Epidemiology, Health College of RSU Daya, Makassar, Indonesia

²Department of Nursing, Hasanuddin University, Makassar, Indonesia

³Department of Biochemistry, Hasanuddin University, Makassar, Indonesia

⁴Department of ENT, Faculty of Medicine, Hasanuddin University, Indonesia

⁵Department Molecular Biology and Immunology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

⁶Department of Microbiology, Tadulako University, Palu, Indonesia

⁷Department of Clinical Pathology, Hasanuddin University, Makassar, Indonesia

⁸Department of Chemistry, Hasanuddin University, Makassar, Indonesia

⁹Department of Oncology, Hasanuddin University, Makassar, Indonesia

Cite this paper:
Andi Nilawati Usman, Yuliana Syam, Rosdiana Natzir, Sutji Pratiwi Rahardjo, Mochammad Hatta, Ressy Dwiyanti, Yuyun Widaningsih, Ainurafiq and Prihantono. The Effect of Giving Trigona Honey and Honey Propolis Trigona to the mRNA Foxp3 Expression in Mice Balb/c Strain Induced by Salmonella Typhi. American Journal of Biomedical Research. 2016; 4(2):42-45. doi: 10.12691/ajbr-4-2-3

Abstract

Immune balance during infection is important to support both the defense of body immune system and prevent excessive immune response. Protein Foxp3, a transcription factor of regulatory T cell has pivotal roles in balancing body immune system. Honey and Propolis have proved their effects to both the proinflamatory and anti inflammatory responses but their effects to the Foxp3 expression need to be investigated. This study was investigated the effect of giving Trigona honey and honey propolis Trigona to the mRNA Foxp3 expression in Balb/c mice induced Salmonella typhi. Results of the study indicated that honey propolis Trigona had the highest effect to the mRNA Foxp3 expression followed by Trigona honey. Both Trigona honey and honey propolis had immunomodulatory effects through the Foxp3 mRNA expression.

Keywords:
Trigona Honey Honey Propolis Foxp3

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