American Journal of Biomedical Research
ISSN (Print): 2328-3947 ISSN (Online): 2328-3955 Website: http://www.sciepub.com/journal/ajbr Editor-in-chief: Hari K. Koul
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American Journal of Biomedical Research. 2016, 4(2), 38-41
DOI: 10.12691/ajbr-4-2-2
Open AccessArticle

Modulatory Effects of Ricinus Communis Leaf Extract on Cadmium Chloride-Induced Hyperlipidemia and Pancytopenia in Rats

Olu Israel OYEWOLE1, , Mojisola Oluwakemi SHOREMI1 and Johnson Olaleye OLADELE1

1Department of Biochemistry, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeri

Pub. Date: May 06, 2016

Cite this paper:
Olu Israel OYEWOLE, Mojisola Oluwakemi SHOREMI and Johnson Olaleye OLADELE. Modulatory Effects of Ricinus Communis Leaf Extract on Cadmium Chloride-Induced Hyperlipidemia and Pancytopenia in Rats. American Journal of Biomedical Research. 2016; 4(2):38-41. doi: 10.12691/ajbr-4-2-2

Abstract

Cadmium (Cd) and its compounds are ubiquitous environmental toxins capable of inducing different types of toxicity in animals and human. Ricinus communis (castor bean) is a known medicinal plant with enormous health benefits. This study investigated the protective effects of ethanolic leaf extract of Ricinus communis on hyperlipidemia and pancytopenia induced by cadmium chloride in Wistar albino rats. Twenty five (25) adult male rats were divided into 5 groups of 5 rats each. Group A received distilled water, group B, C, D and E were administered 5mg/kg body weight CdCl2, group C, D and E were treated with 250, 500 and 1000 mg/kg bw respectively of Ricinus communis leaf extract for 14 days while rats in group B were left untreated. Results obtained showed that administration of cadmium caused significant reduction in cellular elements of the blood (pancytopenia) as well as increase in the level of serum total cholesterol, triglycerides, LDL-cholesterol and coronary heart disease risk ratio while it decrease the level of HDL-cholesterol. Treatment of rats with graded dose of Ricinus communis leaf extract significantly ameliorate the adverse effects of cadmium as it boosted cellular elements of the blood while it also reduced serum total cholesterol, triglycerides, LDL-cholesterol, coronary heart disease risk ratio as well as elevation of HDL-cholesterol level in the blood. We conclude that leaf extract of Ricinus communis has modulatory effects on cadmium induced pancytopenia and hyperlipidemia in rats.

Keywords:
pancytopenia hyperlipidemia cadmium chloride cholesterol Ricinus communis

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References:

[1]  Oyewole O.I. and Akinbamijo T.O. Antioxidative potential of Ageratum conyzoides and Zanthoxylum zanthoxyloides extracts in cadmium-induced oxidative stress in rat tissues. American Journal of Biomedical Research. 3(4): 71-74. 2015.
 
[2]  Sorahan T. and Lancashire R.J. Lung cancer mortality in a cohort of workers employed at a cadmium recovery plant in the United States: an analysis with detailed job histories. Occupational and Environmental Medicine. 54: 194-201. 1997.
 
[3]  Samuelsson G. Drugs of natural origin: a Textbook of Pharmacognosy, 5th Swedish Pharmaceutical Press Stockholm. 2004.
 
[4]  Duke J.A. Handbook of biologically active phytochemicals and their activities. CRC Press, Boca Raton, FL. 1992. Pp22-25.
 
[5]  Kang S.S., Cordell A., Soejarto D.D. and Fong H.S. Alkaloids and flavonoids from Ricinus communis. Nature. 48 (1):155-156. 1985.
 
[6]  Panghal M., Kaushal V. and Yadav J.P. In vitro antimicrobial activity of ten medicinal plants against clinical isolates of oral cancer cases. Ann Clin. Microbiol. Antimicrob. 10: 21. 2011.
 
[7]  Singh P.P., Ambika S. and Chauhan S.M. Activity guided isolation of antioxidants from the leaves of Ricinus communis L. Food chemistry. 114(3): 1069-1072. 2009.
 
[8]  Ilavarasan R.M. and Venkataraman. Anti-inflammatory and free radical scavenging activity of Ricinus communis root extract. J Ethnopharmacol 103: 478-80. 2006.
 
[9]  Lin J.Y. and Liu S.Y. Studies on the antitumour lectins isolated from the seeds of Ricinus communis (castor bean). Toxicon. 24 (8): 757-765. 1986.
 
[10]  Taur D.J., Waghmare M.G., Bandal R.S. and Patil R.Y. Antinociceptive activity of Ricinus communis L. leaves. Asian Pacific Journal of Tropical Biomedicine. 1(2):139-141. 2011.
 
[11]  Sharma S., Vasudevan P. and Madan M. Insecticidal Value of Castor (Ricinus communis) Against Termites. International Biodeterioration. 27: 249-254. 1990.
 
[12]  National Research Council (NRC). Guide for the care and use of laboratory animals 8th Edition. The National Academies Press. 2011.
 
[13]  Dacie J.V. and Lewis S.M. Practical Haematology (7th edn). Churchill Livingstone: Edinburgh; 1228-1234. 1991.
 
[14]  Zoppi F. and Fellini D. Cholesterol estimation, Clinical Chemistry 22, 690-691.
 
[15]  Trinder P. (1969) Estimation of triacylglycerol, Ann. Clin. Biochem. 6: 24-27. 1976.
 
[16]  Wieland H. and Siedel D. HDL cholesterol estimation, Artzl. Lab 27:141-154. 1981.
 
[17]  Friedewald W.T., Levy R.I. and Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge, Clinical Chemistry 18:499-502. 1972.
 
[18]  Huff G.R., Huff W.E., Balog J.M., Rath N.C., Anthony N.B. and Nestor K.E. Stress Response Differences and Disease Susceptibility Reflected by Heterophil to lymphocyte ratio in turkeys selected for increased body weight. Poultry Science 84:709-717. 2005.
 
[19]  Hossain E., Seok Y. and Chul J.Y. Dietary supplementation of plant by products on growth performance, blood parameters and immunity. Journal of medicinal plant research. 6(12), 2458-2467. 2002.
 
[20]  Beloti M.M., de Oliveira P.T., Tagliani M.M. and Rosa A.L. Bone cell responses to the composite of Ricinus communis polyurethane and alkaline phosphatase. J. Biomed. Matter Res. 84 (2): 435-41. 2008.
 
[21]  Okwuasaba F.K., Osunkwo U.A., Ekwenchi M.M., Ekpenyong K.I., Onwukeme K.E., Olayinka A.O., Uguru M.O. and Das S.C. Anticonceptive and estrogenic effects of a seed extract of Ricinus communis var. minor. Journal of Ethnopharmacology. 34:141-145. 1991.
 
[22]  Francis R.B. Jnr. and Johnson C.S. Vascular occlusion in sickle cell disease: current concepts and unanswered questions. Blood. 77: 1405-1414. 1991.
 
[23]  Superko H.R., Nejedly M. and Garrett B. Small LDL and its clinical importance as a new CAD risk factor: a female case study. Progress in Cardiovascular Nursing. 4:167-173. 2002.
 
[24]  Barter P., Gotto A.M., Maroni J.C., Szarek J., Grundy M.S.M., Kastelein J.P. and Bittner V. HDL Cholesterol, VLDL cholesterol and cardiovascular events. New Engl. J. Med., 357(13): 1301-1309. 2007.
 
[25]  Lin M., Hoke C., Ettinger B. Evaluation of homogeneous high-density lipoprotein cholesterol assay on a BM/Hitachi 747-200 analyzer. Clinical Chemistry. 5:1050-1054. 1998.
 
[26]  Clark T.A. and Pierce G.N. Cardiovascular complications of noninsulin-dependent diabetes. J. Pharmacol. Toxicol. Methods. 47, 1-10. 2000.
 
[27]  Kwiterovich P.O. The metabolic pathways of high-density lipoprotein, low-densitylipoprotein, and triglycerides: a current review. The American Journal of Cardiology. 12: 5-10. 2000.
 
[28]  Oyewole O.I, Owoseni A.A. and Faboro E.O. Studies on medicinal and Toxicological properties of Cajanus cajan, Ricinus communis and Thymus vulgaris. Journal of Medicinal Plant Research. 4(19): 2004-2008. 2010.
 
[29]  Kensa V.M. and Syhed Y.S. Phytochemical screening and antibacterial activity on Ricinus communis L. Plant Sciences Feed. 1 (9): 167-173. 2011.
 
[30]  Brown D.J. Herbal prescriptions for better health. Rocklin, CA: Prima Publishing. 139-44. 1996.