Potential Phytochemical, Analgesic and Anticancerous Activities of Cymbopogon citratus Leaf

Md. Irfan Amin Chowdury^{1, 2}, Mitali Debnath², Md. Foyez Ahmad², Mohammad Nazmul Alam^{1, 2,} , Arif Mohammad Saleh¹, Sudipta Chowdhury^{1, 2}, Rajesh Barua¹, Muhammad Moin Uddin Mazumdar^{1, 2} and Abu Hena Mustafa Kamal¹

¹Department of Pharmacy, Faculty of Science and Engineering, International Islamic University Chittagong, College Road, Chittagong, Bangladesh

²Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh

Cite this paper:
Md. Irfan Amin Chowdury, Mitali Debnath, Md. Foyez Ahmad, Mohammad Nazmul Alam, Arif Mohammad Saleh, Sudipta Chowdhury, Rajesh Barua, Muhammad Moin Uddin Mazumdar and Abu Hena Mustafa Kamal. Potential Phytochemical, Analgesic and Anticancerous Activities of Cymbopogon citratus Leaf. American Journal of Biomedical Research. 2015; 3(4):66-70. doi: 10.12691/ajbr-3-4-2

Abstract

Purpose: The aim of this study was to evaluate phytochemical, analgesic and anticancerous activities of Cymbopogon citratus. Methods: Phytochemical screening, analgesic test and anticancerous activities were evaluated by the different chemical tests, writhing test and tail immersion test, brine shrimp lethality bioassay. Results: In the case of acetic acid induced writhing test, C. citratus showed highest percent of inhibition at 400 mg/kg, p.o. which is 49.01% whereas standard diclofenac sodium showed 73.76% at 10 mg/kg, i.p. In the case of tail immersion method, C. citratus exhibited its highest activity at 400 mg/kg, p.o. in 90 min which is 5.56±0.88 whereas diclofenac sodium showed 6.71±0.15 at 10 mg/kg, i.p. in 90 min. In the case of anticancerous activity, methanolic leaf extract of C. citratus demonstrated significant activity which is 113.74 µg/ml and standard vincristine sulphate showed 12.59 µg/ml. Conclusions: The result of phytochemical screening revealed that, methanolic leaf extract of Cymbopogon citratus contain alkaloids, steroids, flavonoids, tannins, saponins and carbohydrates. Methanolic leaf extracts of this plant possess moderate analgesic activity as well as exhibited significant anticancerous activity.

Keywords:
cymbopogon citratus phytochemical screening analgesic diclofenac sodium acetic acid writhing test tail immersion test brine shrimp

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