American Journal of Biomedical Research
ISSN (Print): 2328-3947 ISSN (Online): 2328-3955 Website: http://www.sciepub.com/journal/ajbr Editor-in-chief: Hari K. Koul
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American Journal of Biomedical Research. 2014, 2(4), 70-76
DOI: 10.12691/ajbr-2-4-3
Open AccessArticle

Folic Acid Alleviates Oxidative Stress and Hyperhomocysteinemia Involved in Liver Dysfunction of Hypothyroid Rats

Ehab Tousson1, , Wafaa Ibrahim2, Afrah F. Salama3 and Wesam M. Hussein3

1Department of Zoology, Faculty of Science, Tanta University, Egypt

2Department of medical Biochemistry, Faculty of Medicine, Tanta University, Egypt

3Biochemistry Section, Department of Chemistry, Faculty of Science, Tanta University, Egypt

Pub. Date: November 20, 2014

Cite this paper:
Ehab Tousson, Wafaa Ibrahim, Afrah F. Salama and Wesam M. Hussein. Folic Acid Alleviates Oxidative Stress and Hyperhomocysteinemia Involved in Liver Dysfunction of Hypothyroid Rats. American Journal of Biomedical Research. 2014; 2(4):70-76. doi: 10.12691/ajbr-2-4-3

Abstract

Thyroid hormones are essential for growth and development of the liver. This study evaluated some biochemical alterations in post-pubertal hypothyroidism and its impact on liver functions. Additionally, the ameliorating role of folic acid supplementation was investigated. Fifty male albino rats were randomly divided into five groups (group I, control; group II, folic acid; group III, 0.05% propylthiouracil-induced hypothyroid rats; group IV, Co-treatment; group V post-treatment). There was a significant decrease in plasma T3, body weight, fluid and food intakes, folic acid, ALT, total thiol and tFRAP in hypothyroid rats as compared to control group. On the other hand, a significant increase in TSH, relative liver weight, plasma of total homocysteine, serum total protein, AST, total serum bilirubin, cholesterol and tMDA in hypothyroid rats as compared to control group. This reflects hyperhomocysteinemia and oxidative stress associated with hypothyroid state. Folic acid supplemented after restoration of the euthyroid state presented better amelioration over its concurrent supplementation. If confirmed in human beings, our results could propose that folic acid can be used as an adjuvant therapy in hypothyroidism disorders with thyroxin replacement therapy.

Keywords:
hypothyroidism liver oxidative stress folic acid PTU

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