American Journal of Biomedical Research
ISSN (Print): 2328-3947 ISSN (Online): 2328-3955 Website: Editor-in-chief: Hari K. Koul
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American Journal of Biomedical Research. 2021, 9(2), 36-42
DOI: 10.12691/ajbr-9-2-3
Open AccessArticle

Relationship between COVID-19 Infection and ABO Blood Groups Differences: A Tertiary Centre Experience in Al-Madinah, Saudi Arabia

Abdulhalem A. Jan1, Ahmed M. Aljeraisi2, Abdullah M. Algarni3, Mohammed A. Almozini4, Nashwa A. Alsyed5, Suliman A. Alharbi6, Muhammad A. Tobaiqi7, Hemaed Aljabri8, Nasser M. Mulla1, 7, Alaa A. Alsayed9 and Salah Mohamed El Sayed10, 11,

1Laboratory and Blood Bank Director, King Fahad Hospital, Al-Madinah, Saudi Arabia

2Rehabilitation Hospital, Al-Madinah, Saudi Arabia

3Infection Control, King Fahad Hospital, Al-Madinah, Saudi Arabia

4Laboratory, King Fahad Hospital, Al-Madinah, Saudi Arabia

5Quality control, King Fahad Hospital, Al-Madinah, Saudi Arabia

6Immunology department, King Fahad Hospital, Al-Madinah, Saudi Arabia

7Department of Medicine, Taibah University, Al-Madinah, Saudi Arabia

8Blood Bank Department, King Fahad Hospital, Madinah

9Chief Risk Officer, Madinah Health Cluster, Al-Madinah, Saudi Arabia

100Department of Clinical Biochemistry and Molecular Medicine, Taibah Faculty of Medicine, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia

111Department of Medical Biochemistry, Sohag Faculty of Medicine, Sohag University, Egypt

Pub. Date: November 04, 2021

Cite this paper:
Abdulhalem A. Jan, Ahmed M. Aljeraisi, Abdullah M. Algarni, Mohammed A. Almozini, Nashwa A. Alsyed, Suliman A. Alharbi, Muhammad A. Tobaiqi, Hemaed Aljabri, Nasser M. Mulla, Alaa A. Alsayed and Salah Mohamed El Sayed. Relationship between COVID-19 Infection and ABO Blood Groups Differences: A Tertiary Centre Experience in Al-Madinah, Saudi Arabia. American Journal of Biomedical Research. 2021; 9(2):36-42. doi: 10.12691/ajbr-9-2-3


Controversial factors affecting COVID-19 infection include age, ethnicity, blood groups and Rh factor were investigated here. This study enrolled 2012 participants: COVID-19 cases (1006 patients), and control group (1006 subjects), 50.9% were Saudis and 49.1% were non-Saudis. Mean age for all participants was 36.0±12.7 years and ranged from 8 to 80 years. Mean age was 38.6+15.3 years for COVID-19+ve cases and 33.4±8.6 years for controls. Mean age significantly differed in COVID-19+ve cases from controls (p<0.001). COVID-19 infection was significant in Saudi participants compared to non-Saudi participants (p<0.001). In COVID-19 group, the frequencies of blood groups O, A, B and AB were 44.5%, 31.3%, 19.7% and 4.5%, respectively. The percentage of COVID-19 infection was higher in subjects having blood groups O and A. Regarding Rh factor, 94.0% of all participants were Rh+ve and 6.0% were Rh-ve. Among COVID+ve cases, 93.4% were Rh positive cases and 6.6% were Rh negative cases, while in the controls, 94.5% were Rh+ve and 5.5% were Rh-ve. The number of COVID-19+ve cases exceeded the number of healthy controls in A+ve subjects but not in O+ve and B+ve subjects. In multivariate analysis, people with blood groups B and AB were less likely to be infected (p =0.049) compared to those with groups O and A. In conclusion, older adults had greater risk of COVID-19 infection. Gatherings culture increased COVID-19 infection. Individuals with blood groups B and AB are less likely to get COVID-19 infection than O and A subjects. Rh+ve in O+ve and A+ve is associated with increased COVID-19 infection.

COVID-19 Rh+ve Rh-ve ABO blood groups ethnicity COVID-19 infection

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