Applied Ecology and Environmental Sciences
ISSN (Print): 2328-3912 ISSN (Online): 2328-3920 Website: Editor-in-chief: Alejandro González Medina
Open Access
Journal Browser
Applied Ecology and Environmental Sciences. 2021, 9(6), 607-612
DOI: 10.12691/aees-9-6-5
Open AccessReview Article

A Review on Potentialities of Selenium Nanoparticles and Its Application Using Air Borne Fungus

Sammi Parvin1, Salman Khan1, Pravej Alam2, Tajdar H. Khan3, Moayad Khataibeh4, Mushtaq A. Khan5, Abdus Samad6, Abu Baker1 and Shazia Mansoor7,

1Nanotechnology Lab 6, Department of Biosciences, Integral University, Lucknow - 226026, India

2Department of Biology, College of Science and Humanities, Prince Sattam bin Abdulaziz University, 11942, Alkharj, KSA

3Aspire Bio – solutions, Pihani, Hardoi, UP- 241406, India

4Department of Medical Laboratory Sciences, College of Science, Al-Balqa’ Applied University, Jordan.

5Department ofMicrobiology and Immunology, College of Medicine and Health Sciences, UAE University, Al – Ain, UAE

6Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tishk International University, Erbil, Kurdistan Region, Iraq

7Department of Research, Jawaharlal Nehru Cancer Hospital and Research Centre, Bhopal – 462001, India

Pub. Date: June 22, 2021

Cite this paper:
Sammi Parvin, Salman Khan, Pravej Alam, Tajdar H. Khan, Moayad Khataibeh, Mushtaq A. Khan, Abdus Samad, Abu Baker and Shazia Mansoor. A Review on Potentialities of Selenium Nanoparticles and Its Application Using Air Borne Fungus. Applied Ecology and Environmental Sciences. 2021; 9(6):607-612. doi: 10.12691/aees-9-6-5


Airborne fungal pathogens are known as pathogens and cause number of diseases including infections of skin and severe respiratory tract diseases. The presence of mycotoxins in fungi are found responsible for causing infections and these mycotoxins degrade substances also. Keeping in view of this property, a number of researchers explored different fungal species to synthesize nanoparticles which exhibit promising therapeutic properties. Some of the examples of fungi used for nanoparticles include Aspergillus and Trichoderma. The biosynthesis of fungi based nanoparticles is safe, eco-friendly, biocompatible and low cost. Present review deals with the synthesis of selenium nanoparticles using air borne fungus. Selenium is one of the micronutrient required by plants in trace amounts also has therapeutic properties. But large amount of selenium is toxic and may be hazadorous when enters via food chain. Nanoselenium has similar bioactivity like other forms of selenium in humans and has many biological applications in the field of medical and pharmaceutical research to combat threats to number of diseases and for human health. Biogenic SeNPs have antimicrobial, anticancer (cytotoxic), antioxidant activity. The present review emphasizes on myconanotechnology and its application, synthesis of myconanoparticles. Application of selenium and its therapeutic properties as antimicrobial, anticancer and antiviral, whereas can be used as remedy for number of diseases. Collectively, self-assembly of SeNPs-fungal complexes affects their (patho) biological identity, which may impact human health and ecology.

selenium air borne fungus SeNPs nanotechnology and mycogenic

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit


[1]  Worrall, E.A., Hamid, A., Mody, K.T., Mitter, N. and Pappu, H.R, “Nanotechnology for Plant Disease Management,” Agronomy, 8 (285). Nov.2018.
[2]  Jogaiah, S., Abdelrahman, M., Tran, L.S.P. and Ito, S.I, “Different mechanisms of Trichoderma virens-mediated resistance in tomato against Fusarium wilt involves the jasmonic and salicylic acid pathways,” Mol Plant Pathol, 19 (4). 870-882. 2018.
[3]  Dhillon, G.S., Brar, S.K., Kaur, S. and Verma, M, “Green approach for nanoparticle biosynthesis by fungi: current trends and applications,” Critical Reviews in Biotechnology, 32 (1). 49-73. Jun.2011.
[4]  Zhang, S., Luo, Y., Zeng, H., Wang, Q., Tian, F., Song, J. and Cheng, W.H, “Encapsulation of selenium in chitosan nanoparticles improves selenium availability and protects cells from selenium-induced DNA damage response,” J Nutr Biochem, 22 (12). 1137-1142. Dec.2011.
[5]  Wang. H., Zhang, J. and Yu, H, “Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice,” Free Radic Biol Med, 42 (10). 1524-1533. May.2007.
[6]  Nuttall, K.L, “Evaluating selenium poisoning,” Ann Clin Lab Sci, 36 (4). 409-420. 2006.
[7]  Dhanjal, S. and Cameotra, S.S, “Aerobic biogenesis of selenium nanospheres by Bacillus cereus isolated from coalmine soil,” Microb Cell Factories, 9 (52). 2010.
[8]  Tran, P. and Webster, T.J, “Enhanced osteoblast adhesion on nanostructured selenium compacts for anti-cancer orthopedic applications,” Int J Nanomedicine, 3 (3). 391-396. 2008.
[9]  Khiralla, G.M. and El-Deeb, B.A, “Antimicrobial and antibiofilm effects of selenium nanoparticles on some food borne pathogens,” LWT Food Sci. Technol, 63 (2). 1001-1007. Oct.2015.
[10]  Forootanfar, H., Adeli-Sardou, M., Nikkhoo, M., Mehrabani, M., Bagher, A.H., Ahmad, R.S. and Shakibaie, M, “Antioxidant and cytotoxic effect of biologically synthesized selenium nanoparticles in comparison to selenium dioxide,” J Trace Elem Med Biol, 28 (1). 75-79. Jan.2014.
[11]  Mousa, A. A., Hassan, A., Mahindra, R., Ernest, S.G. and Kamel, A. A, “Myconanoparticles: synthesis and their role in phytopathogens management. Article; Agriculture and Environmental Biotechnology,” Biotechnology & Biotechnological Equipment, 29 (2). 221-236. Mar.2015.
[12]  Mohanpuria, P., Rana, N.K. and Yadav, S.K, “Biosynthesis of nanoparticles, technological concepts and future applications,” J Nanoparticle Res, 7. 9275-9280. Mar.2008.
[13]  Gaikwad, C. S., Birla, S.S., Ingle, A.P., Gade, A.K., Marcato, P.D., Rai, M.K. and Duran, D, “Screening of different Fusarium species to select potential species for the synthesis of silver nanoparticles,” J Braz Chem Soc, 24 (12). 1974-1982. 2013.
[14]  Krishna, G. and Singara, C.M, “Synthesis of silver nanoparticles by chemical and biological methods and their antimicrobial properties,” Journal of Experimental Nanosciencei, 11 (9). 714-721. Jan.2016.
[15]  Angamuthu, A., Venkidusamy, K. and Muthuswami, R. R, “Synthesis and characterization of nano-selenium and its antibacterial response on some important human pathogens,” Current Science, 116 (2). 285-290. Jan.2019.
[16]  Zhang, L., Li, D. and Gao, P, “Expulsion of selenium/protein nanoparticles through vesicle-like structures by Saccharomyces cerevisiae under microaerophilic environment,” World J Microbiol Biotechnol, 28. 3381-3386. Sep.2012.
[17]  Elahian, F., Reiisi, S., Shahidi, A. and Mirzaei, S.A, “High-throughput bioaccumulation, biotransformation, and production of silver and selenium nanoparticles using genetically engineered Pichia pastoris,” Nanomedicine: Nanotechnology, Biology, and Medicine, 13. 853-861. 2017.
[18]  Zare, B., Babaie, S., Setayesh, N. and Shahverdi, A.R, “Isolation and characterization of a fungus for extracellular synthesis of small selenium nanoparticles,” Nanomed J, 1 (1). 14-20. 2013.
[19]  Xinjin, L., Magali, A.M.P., Kenneth, C.N., Philipp, E. Joerg, F., Laszlo, C. and Geoffrey, M. G, “Fungal formation of selenium and tellurium nanoparticles,” Applied Microbiology & Biotechnology, 103. 7241-7259. July.2019.
[20]  Shreya, M.J., Savitha, D. B., Sudisha, J. and Shin-ichi, I, “Mycogenic Selenium nanoparticles as potential new generation broad spectrum antifungal molecules,” Biomolecules, 9 (419). 11-16. Aug.2019.
[21]  Lanzuise, S., Ruocco, M., Scala, V., Woo, S.L., Scala, F., Vinale, F. and Lorito, M, “Cloning of ABC transporter-encoding genes in Trichoderma spp. to determine their involvement in biocontrol,” J Plant Pathol, 84. 184. Jan.2002.
[22]  Boregowda, N., Puttaswamy, H., Harischandra, S. P., Hunthrike, S. S. and Nagaraja, G, “Trichogenic-selenium nanoparticles enhance disease suppressive ability of Trichoderma against downy mildew disease caused by Sclerospora graminicola in pearl Millet,” Scientific Reports, 7 (2612). Jun.2017.
[23]  Kieliszek, M., Bła, Z. S., Gientka, I. and Bzducha-Wróbel, A, “Accumulation and metabolism of selenium by yeast cells,” Appl Microbiol Biotechnol, 99. 5373-5382. May.2015.
[24]  Mary, C. S., Carla, E. R., Todd, D., DeJournett, Katie, S., Karl, W. and Cara, M. S, “Fungal Bioremediation of Selenium-Contaminated Industrial and Municipal Wastewaters,” Frontiers in Microbiology, 11 (2105). Sep.2020.
[25]  Rosenfeld, C.E., Kenyon, J.A., James, B.R. and Santelli, C.M, “Selenium (IV,VI) reduction and tolerance by fungi in an toxic environment,” Geobiology, 15 (3). 441-452. Jan.2017.
[26]  Amit, K., Sravani, T., Mohd, A.S., Pooladanda, V. and Chandraiah, G, “Therapeutic applications of selenium nanoparticles,” Biomedicine & Pharmacotherapy, 111. 802-812. 2019.
[27]  Luo, H., Wang, F., Bai, Y., Chen, T. and Zheng, W, “Selenium nanoparticles inhibit the growth of HeLa and MDA-MB-231 cells through induction of S phase arrest,” Colloids Surf B Biointerfaces, 94. 304-308. Jun.2012.
[28]  Zeng, H. and Combs, G. F, “Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion,” J Nutr Biochem, 19 (1). 1-7. Jan.2008.
[29]  Pi, J., Jin, H., Liu, R., Song, B., Wu, Q., Liu, L., Jiang, J., Yang, F., Cai, H. and Cai, J, “Pathway of cytotoxicity induced by folic acid modified selenium nanoparticles in MCF-7 cells,” Appl Microbiol Biotechnol, 97 (3). 1051-1062. Feb.2013.
[30]  Yazdi, M.H., Varastehmoradi, B., Faghfuri, E., Mavandadnejad, F., Mahdavi, M. and Shahverdi, A.R, “Adjuvant effect of biogenic selenium nanoparticles improves the immune responses and survival of mice receiving 4T1 cell antigens as vaccine in breast cancer murine model,” J Nanosci Nanotechnol, 15 (12). 10165-10172. Dec.2015.
[31]  Rao, L., Ma, Y., Zhuang, M., Luo, T., Wang, Y. and Hong, A, “Chitosan-decorated selenium nanoparticles as protein carriers to improve the in vivo half-life of the peptide therapeutic BAY 55-9837 for type 2 diabetes mellitus,” Int J Nanomed, 9. 4819-4828. Oct.2014.
[32]  Li, Y., Lin, Z., Guo, M., Xia, Y., Zhao, M., Wang, C., Xu, T., Chen, T. and Zhu, B, “Inhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus,” Int J Nanomedicine, 12. 5733-5743. Aug.2017.
[33]  Farag M.M., Gharieb S.E., Rasha M.F. and Ahmed I.E, “Biomolecules-mediated synthesis of selenium nanoparticles using Aspergillus oryzae fermented Lupin extract and gamma radiation for hindering the growth of some multidrug-resistant bacteria and pathogenic fungi,” Microbial Pathogenesis, 122. 108-116. Sep.2018.